Animal-Free IL-34 蛋白, Human (His)

IL-34 protein is an important cytokine that promotes proliferation, survival, and differentiation of monocytes and macrophages. It plays a key role in innate immunity and inflammation by promoting the release of pro-inflammatory chemokines. Animal-Free IL-34 Protein, Human (His) is the recombinant human-derived animal-FreeIL-34 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-34 Protein, Human (His) is 222 a.a., with molecular weight of ~26.17 kDa.

IL-34 蛋白是一种重要的细胞因子，促进单核细胞和巨噬细胞的增殖、存活和分化。它的作用延伸到促进促炎趋化因子的释放，从而在先天免疫和炎症过程中发挥关键作用。此外，IL-34 在调节破骨细胞增殖和分化、影响骨吸收方面发挥着关键作用。通过 CSF1R 及其下游效应器的信号传导，IL-34 刺激 MAPK1/ERK2 和 MAPK3/ERK1 的磷酸化。IL-34 作为同二聚体存在，与 CSF1R 特异性相互作用，进一步促进其复杂的调控网络。

Measure by its ability to induce human peripheral blood monocytes (PBMCs) proliferation. The ED₅₀ for this effect is <30 pg/mL.

Human

E. coli

C-His

Q6ZMJ4 (N21-P242)

146433  [NCBI]

MNEPLEMWPLTQNEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCEVPSPQSCSPEPSLQYAATQLYPPPPWSPSSPPHSTGSVRPVRAQGEGLLP

Approximately 26.17 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 8.0.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.