Calcitonin/CALCA 蛋白, Human (HEK293, N-His)

Calcitonin, encoded by the CALCA gene, induces a swift yet transient reduction in blood calcium and phosphate levels by facilitating the incorporation of these ions into the bones. This physiological response highlights Calcitonin's role in regulating mineral homeostasis and underscores its impact on skeletal dynamics. Additionally, Katacalcin, a peptide derived from the same gene, emerges as a potent factor in lowering plasma calcium levels, further emphasizing the multifaceted influence of Calcitonin in orchestrating calcium metabolism. Calcitonin/CALCA Protein, Human (HEK293, N-His) is the recombinant human-derived Calcitonin/CALCA protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Calcitonin/CALCA Protein, Human (HEK293, N-His) is 116 a.a., with molecular weight of ~16.28 kDa.

降钙素由 CALCA 基因编码，通过促进这些离子融入骨骼，从而导致血钙和磷酸盐水平迅速而短暂地降低。这种生理反应凸显了降钙素在调节矿物质稳态中的作用，并强调了它对骨骼动力学的影响。此外，Katacalcin（一种源自同一基因的肽）成为降低血浆钙水平的有效因素，进一步强调了降钙素在协调钙代谢中的多方面影响。

Human

HEK293

C-6*His

P01258 (A26-N141)

796  [NCBI]

APFRSALESSPADPATLSEDEARLLLAALVQDYVQMKASELEQEQEREGSSLDSPRSKRCGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAPGKKRDMSSDLERDHRPHVSMPQNAN

Approximately 16.28 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.