Cardiotrophin-1/CTF1 蛋白, Human (CHO)

Cardiotrophin-1/CTF1 Protein, Human (CHO), a member of IL-6 family of cytokines, is a key regulator of energy homeostasis and of glucose and lipid metabolism.

心肌营养素 (CT)-1 属于细胞因子 IL-6 家族^[1]。心肌营养蛋白-1 (CT1) 在神经干细胞的分化、发育和存活中发挥着重要作用。CT1 在神经组织发育中发挥关键作用，并在神经损伤或死亡中具有促进存活、抗凋亡的作用。CT1 诱导交感神经元表型转换，促进中枢神经系统多巴胺能神经元和外周睫状神经元的存活^[2]。

The ED₅₀ is <0.4 ng/mL as measured by TF-1 cells.

Human

CHO

Tag Free

Q16619 (S2-A201)

1489  [NCBI]

SRREGSLEDPQTDSSVSLLPHLEAKIRQTHSLAHLLTKYAEQLLQEYVQLQGDPFGLPSFSPPRLPVAGLSAPAPSHAGLPVHERLRLDAAALAALPPLLDAVCRRQAELNPRAPRLLRRLEDAARQARALGAAVEALLAALGAANRGPRAEPPAATASAASATGVFPAKVLGLRVCGLYREWLSRTEGDLGQLLPGGSA

24-26 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against PBS.

<0.2 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. López-Yoldi M, et al. Role of cardiotrophin-1 in the regulation of metabolic circadian rhythms and adipose core clock genes in mice and characterization of 24-h circulating CT-1 profiles in normal-weight and overweight/obese subjects. FASEB J. 2017 Apr;31(4):1639-1649.  [Content Brief]

  [2]. Peng L, et al. Cardiotrophin-1 stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through PI3K/Akt-dependent signaling pathways. Cytotechnology. 2017 Dec;69(6):933-941.  [Content Brief]