CASPR2 蛋白, Mouse (HEK293, His)

CASPR2 protein has PDZ domain binding activity and plays a crucial role in synaptic transmission, nervous system development and synaptic organization. It is essential for processes such as glutamatergic neuronal differentiation and limbic system development, and is located in cellular components such as cerebellar synapses and presynaptic active zone membranes. CASPR2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CASPR2 protein, expressed by HEK293 , with C-His, C-10*His labeled tag. The total length of CASPR2 Protein, Mouse (HEK293, His) is 1235 a.a., with molecular weight of 140-150 kDa.

CASPR2 蛋白表现出 PDZ 结构域结合活性，并参与化学突触传递、神经系统发育和突触组织等多种过程。它在谷氨酸能神经元分化、边缘系统发育和神经元投射发育等过程的上游或内部发挥着至关重要的作用。CASPR2位于各种细胞成分中，包括小脑颗粒细胞至浦肯野细胞突触、主轴突和突触前活性区膜，并作为膜和电压门控钾通道复合体的组成部分。CASPR2 在树突和兴奋性突触中活跃，在中枢神经系统和神经视网膜中显着表达。它已在自闭症谱系障碍和皮质发育不良-局灶性癫痫综合征的背景下进行了研究。此外，其人类直系同源物，特别是 CNTNAP2（接触蛋白相关蛋白 2），与皮特-霍普金斯综合征、自闭症谱系障碍、沟通障碍、皮质发育不良-局灶性癫痫综合征和社交恐惧症等疾病有关。该基因在 CNS E18 (RPKM 4.2)、全脑 E14.5 (RPKM 3.7) 和其他七个组织中表现出偏向表达，突显其参与各种组织的关键发育和神经过程。

Immobilized Recombinant Mouse CASPR2 at 0.5 μg/mL (100 μL/well) can bind Biotinylated Recombinant Human Contactin-1 Protein. The ED₅₀ for this effect is 0.7407 μg/mL.

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  Immobilized Recombinant Mouse CASPR2 at 0.5 μg/ml (100 μl/well) can bind Biotinylated Recombinant Human Contactin-1 Protein. The ED₅₀ for this effect is 0.7407 μg/mL.

Mouse

HEK293

C-His;C-10*His

NP_001004357.2 (A28-S1262)

66797  [NCBI]

APSTFQKCDEPLISGLPHVSFSSSSSLSSSYAPGYAKINKRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNVNSDSVVRHDLQHAVVARYVRVVPLDWNGEGHIGLRAEVYGCAYWADVINFDGHGVLPYRFRNKKMKTLKDVIALKFKTSESEGVLLHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVTSGSLLDDHHWHSVLIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSNRKNFKGCMESINYNGVNITDLARRKKLEPSNMGNLSFSCVEPYTVPVFFNATSYLEVPGRLNQDLFSVSFQFRTWNPSGLLLFSHFADNLGNVEIDLVESKVGVHINNTQTKTSQIDISSGSGLNDGQWHEVRFLAKENFAVLTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNHMNNASYSALQPSFQGCMQLIQVDDQLVNLYEVAHRKPGSFANVTIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCEAYKHLGQTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIVSHDLQMQTTVVGYNPEKYSVTQLIYSASMDQISAITSSAEYCEQYVSYFCRMSRLLNTPDGSPYTWWVGKANEKHYYWGGSEPGIQKCACGIERNCTDPKYYCNCDADYKQWRKDAGFLSYKDHLPVSQVVVGDTDRQGSEAKLSVGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLIPRGVFLENLGNTDFIKLELKSATEVSFSFDVGNGPVEIVVRSPSPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYSQLFVGGAGGQQGFLGCIRSLRMNGVTLDLEERAKVTSGFKSGCSGHCTSYGANCENGGKCIEKYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPAVTARDTGSRAENSADQQQHLAPDLAQEQIHFSFSTTKAPCILLYVSSLTTDFLAVLVKPTGNLQIRYNLGGTREPFNIDVDHRNMANGQPHSVNITRHERTIILKLDHYPAVGYHLPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQFNHIAPLKAALRQTNASAHVHIQGELVESNCGASPLTLSPMSSATDPWHLDHLDSASADFPYNPGQGQAIRNGVNRNS

140-150 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in PBS, pH 7.4. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose). 组成 Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.