CD68 蛋白, Rat (HEK293, His)

CD68 is a protein belonging to the LAMP (lysosome-associated membrane protein) family. It is expressed primarily in macrophages, monocytes, and dendritic cells, serving as a marker for these immune cells. CD68 Protein, Rat (HEK293, His) is the recombinant rat-derived CD68 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD68 Protein, Rat (HEK293, His) is 295 a.a., with molecular weight of 60-110 kDa.

CD68 是一种属于 LAMP（溶酶体相关膜蛋白）家族的蛋白质。它主要在巨噬细胞、单核细胞和树突细胞中表达，作为这些免疫细胞的标记。CD68 定位于溶酶体，溶酶体是负责降解各种分子的细胞器。作为一种溶酶体蛋白，CD68 在巨噬细胞和树突状细胞加工和呈递抗原中发挥着至关重要的作用。它参与吞噬作用，即这些免疫细胞吞噬和消化异物颗粒（例如细菌和细胞碎片）的过程。CD68 还与炎症和组织重塑有关，因为它的表达可以响应炎症刺激而上调。此外，CD68 已被确定为某些疾病（包括癌症）的潜在生物标志物，其表达与肿瘤进展和不良预后相关。了解 CD68 的功能和影响可以为免疫反应和疾病发病机制提供有价值的见解。

Measured by its binding ability in a functional ELISA. When Recombinant Rat S100A8 is immobilized at 10 µg/mL (100 µL/well) can bind Recombinant Rat CD68 Protein. The ED₅₀ for this effect is 9.492 μg/mL.

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  Measured by its binding ability in a functional ELISA. When Recombinant Rat S100A8 is immobilized at 10 µg/mL (100 µL/well) can bind Recombinant Rat CD68 Protein. The ED₅₀ for this effect is 9.492 μg/mL.

Rat

HEK293

C-6*His

Q4FZY1 (K20-S295)

287435  [NCBI]

KDCPHKKAATLLPSFTETPTTTGSTASPTTTHRPTTTSHRPTTTSHRPTTTSHRPTTTSHRPTTTSHRPTTTSHGNATVSPTTNSPGFSTVGPHPGPPPPSPSPSPSSTGALGNYTWTNGSQPCVQLQAQIQIRILYLTQGGKKAWGLSVLNPNKTKVQGGCDSAHPHLALSFPYGQLTFGFKQDRHQSHSTVYLNYMAVEYNVSFPQAAQWTFSAQNSSLQELQAPLGQSFCCGNTSIVLSPAIHLDLLSLRLQAAQLPDKGHFGPCFSCASDQS

Approximately 60-110 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.