CD79 蛋白, Human (HEK293, Flag-His)

CD79A Protein is crucial for initiating the B-cell antigen receptor complex (BCR) signal transduction cascade upon antigen binding. It facilitates BCR complex internalization, trafficking to late endosomes, and antigen presentation. CD79A ensures BCR surface expression, pro- and pre-B-cell differentiation, and autophosphorylation of SYK by binding to BLNK. It interacts with FYN and LYN kinases, enhancing their activity. CD79A, forming a disulfide-linked heterodimer with CD79B, constitutes the BCR complex. It interacts with SYK and BLNK, orchestrating essential signaling events in B-cell development. CD79 Protein, Human (HEK293, Flag-His) is a recombinant protein dimer complex containing human-derived CD79 protein, expressed by HEK293, with C-His, C-Flag labeled tag. CD79 Protein, Human (HEK293, Flag-His), has molecular weight of ~37.5 kDa.

CD79A 蛋白对于响应抗原与 B 细胞抗原受体复合物 (BCR) 结合而启动信号转导级联至关重要。它在内化 BCR 复合物、将其运输到晚期内体以及促进抗原呈递方面发挥着至关重要的作用。CD79A 对于 BCR 的表面表达以及原 B 细胞和前 B 细胞的有效分化也是必需的。它通过与 BLNK 结合并使其接近 SYK，从而促进 SYK（一种关键信号分子）的自身磷酸化和激活，从而使 BLNK 磷酸化。CD79A 还与某些 Src 家族酪氨酸激酶（例如 FYN 和 LYN）相互作用，从而增加其活性。值得注意的是，它在未成熟 B 细胞发育过程中抑制 BCR 信号传导。CD79A 与 CD79B 形成二硫键连接的异二聚体，它们一起构成 B 细胞抗原受体复合物，其中 α/β 链异二聚体与由两条重链组成的抗原特异性膜结合表面免疫球蛋白非共价结合，两条轻链。CD79A 通过其磷酸化 ITAM 结构域与 SYK 相互作用，促进 SYK 自身磷酸化和激活。此外，当 Tyr-210 上磷酸化时，CD79A 与 BLNK/SLP65 的 SH2 结构域相互作用，使 BLNK 与 SYK 接近，并允许 SYK 磷酸化 BLNK，这对于 BCR 运输到晚期内体是必需的。

Human

HEK293

C-His;C-Flag

P11912 (L33-R143)&P40259 (A29-D159)

973  [NCBI]&974  [NCBI]

Approximately 37.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.