2. 重组蛋白
  3. CD Antigens
  4. B Cell CD Proteins
  5. Ig-β/CD79b
  6. CD79B 蛋白, Rat (HEK293, Fc)

CD79B 蛋白, Rat (HEK293, Fc)

目录号: HY-P75658
产品使用指南

CD79B Protein，也称为 B29 或 Igβ，与免疫球蛋白和 mb1 (Igα, CD79a) 一起是 B 细胞受体的重要组成部分，并且是 B 细胞发育所必需的。大鼠 CD79B 蛋白包含 228 个氨基酸，其氨基酸序列与小鼠和人类对应物的氨基酸序列差异分别为85%和69%。B 细胞抗原受体 (BCR) 信号成分 Igβ (CD79B) 和辅助受体 CD19 作为替代 B 细胞信号传导模块，通过整合的 ITAM/PI3K 信号传导促进 B 淋巴瘤和正常 B 细胞的存活。CD79B 的缺失会导致 N-聚糖成熟受阻和未成熟蛋白质的积累。CD79B 蛋白, Rat (HEK293, Fc) 是重组的 CD79B 蛋白，由 HEK293 表达，带有 C-hFc 标签。CD79B 蛋白, Rat (HEK293, Fc) 全长 133 个氨基酸，分子量约为 ~50 kDa。

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100 μg   询价  

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描述

CD79B Protein, also known as B29 or Igβ, is an essential component of the B cell receptor along with immunoglobulin and mb1 (Igα, CD79a) and is absolutely required for B cell development. Rat CD79B protein comprises 228 amino acids, and its amino acid sequence is 85 and 69% identical with the mouse and human counterparts, respectively. The B-cell antigen receptor (BCR) signaling component Igβ (CD79B) and the co-receptor CD19 act as an alternative B-cell signaling module that promotes the survival of B lymphoma and normal B cells via integrated ITAM/PI3K signaling. The loss of CD79B causes a block in N-glycan maturation and accumulation of immature proteins[1][2][3]. CD79B Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD79B protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD79B Protein, Rat (HEK293, Fc) is 133 a.a., with molecular weight of ~50 kDa.
研究背景

人类、小鼠和大鼠 B29 (Ig beta, CD79b) 基因在序列和组织上高度保守，并表现出严格的 B 细胞特异性表达。在人类和大鼠基因组中，B29 基因位于骨骼肌特异性 Na 通道 α 亚基 (SCN4A) 基因和垂体特异性生长激素 (GH-N) 基因之间。大鼠 B29/Ig-β 基因长 3.1 kb，有 6 个外显子，与 Na 通道和 GH 基因分别相隔 3.3 和 9.3 kb[1][2]。
B 细胞受体 (BCR) 由表面结合的免疫球蛋白 (Ig) 和包含 CD79A 和 CD79B 组成的异二聚体信号单元组成。识别同源抗原后，受体会启动 B 细胞发育和功能的重要信号[3]。
种属

Rat
表达系统

HEK293
标签

C-hFc
蛋白编号

O70153 (V26-D158)
基因 ID

171055  [NCBI]
蛋白结构
N-term
CD79B (V26-D158)
Accession # O70153
hFc
C-term
同用名
B-cell antigen receptor complex-associated protein beta chain; CD79b; B29; IGB
分子量

Approximately 50 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CD79B Protein, Rat (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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