2. 重组蛋白
  3. CD Antigens Receptor Proteins
  4. Stem Cell CD Proteins Epithelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  5. CD66d/CEACAM3 Immunoglobulin-like Cell Adhesion Molecules
  6. CEA Cell Adhesion Molecule 3 (CEACAM3)
  7. CEACAM3 蛋白, Human (His-SUMO)

CEACAM3 蛋白, Human (His-SUMO)

目录号: HY-P72130
产品使用指南

CEACAM3 蛋白是一种关键的粒细胞受体，可有效协调 CEACAM 结合微生物（如奈瑟氏菌属、莫拉氏菌属和嗜血杆菌属）的非调理素依赖性吞噬作用。这一作用使 CEACAM3 处于先天免疫系统中病原体清除的最前沿。CEACAM3 蛋白, Human (His-SUMO) 是重组的 CEACAM3 蛋白，由 E. coli 表达，带有 N-6*His, N-SUMO 标签。CEACAM3 蛋白, Human (His-SUMO) 全长 121 个氨基酸，分子量约为 ~29.1 kDa。

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描述

The CEACAM3 protein is a key granulocyte receptor that effectively orchestrates the opsonin-independent phagocytosis of CEACAM-bound microorganisms such as Neisseria spp., Moraxella spp., and Haemophilus spp. This role places CEACAM3 at the forefront of pathogen clearance in the innate immune system. CEACAM3 Protein, Human (His-SUMO) is the recombinant human-derived CEACAM3 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of CEACAM3 Protein, Human (His-SUMO) is 121 a.a., with molecular weight of ~29.1 kDa.
研究背景

CEACAM3 蛋白是一种关键的粒细胞受体，可协调 CEACAM 结合微生物（包括奈瑟菌属、莫拉氏菌属和嗜血杆菌属等病原体）的高效非调理素依赖性吞噬作用。这一重要作用使 CEACAM3 处于先天免疫系统内病原体清除的最前沿。在病原体吞噬过程中，CEACAM3 负责刺激 RAC1，进一步促进病原体吞噬的细胞过程。值得注意的是，CEACAM3 与 S100A9/钙卫蛋白进行钙依赖性相互作用，这是一种独立于 CEACAM3 磷酸化而发生的动态相互作用。这种复杂的功能网络强调了 CEACAM3 在协调针对一系列微生物的有效免疫反应中的多方面作用。
种属

Human
表达系统

E. coli
标签

N-6*His;N-SUMO
蛋白编号

P40198 (K35-G155)
基因 ID
蛋白结构
N-term
6*His-SUMO
CEACAM3 (K35-G155)
Accession # P40198
C-term
同用名
carcinoembryonic ; Carcinoembryonic antigen CGM1; Carcinoembryonic antigen gene family member 1; carcinoembryonic antigen related cell adhesion molecule 3; Carcinoembryonic antigen-related cell adhesion molecule 3; cd66 d; CD66d; CD66d antigen; CEA; CEACAM 3; CEACAM-3; Ceacam3; CEAM 3; CEAM-3; CEAM3; CEAM3_HUMAN; CGM1; Nonspecific cross reacting antigen; W264; W282
氨基酸序列

KLTIESMPLSVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNSLIVGYVIGTQQATPGAAYSGRETIYTNASLLIQNVTQNDIGFYTLQVIKSDLVNEEATGQFHVYQENAPGLPVGAVAG

分子量

Approximately 29.1 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CEACAM3 Protein, Human (His-SUMO) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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