CHAC1 蛋白, Human (Strep)

The CHAC1 protein cleaves glutathione, inducing apoptosis via the ATF4-ATF3-DDIT3/CHOP cascade. It acts as a negative regulator of the Notch signaling pathway, promoting neurogenesis by inhibiting Notch cleavage. CHAC1 Protein, Human is the recombinant human-derived CHAC1 protein, expressed by E. coli , with C-Strep. The total length of CHAC1 Protein, Human is 221 a.a., .

CHAC1 是细胞过程中的关键参与者，可催化谷胱甘肽裂解为 5-氧代-L-脯氨酸和 Cys-Gly 二肽，与其他 γ-谷氨酰肽相比，对谷胱甘肽表现出特异性。其对谷胱甘肽的酶促作用至关重要，因为谷胱甘肽的消耗是细胞凋亡启动和执行的重要因素。CHAC1 进一步充当未折叠蛋白反应途径中的促凋亡成分，介导 ATF4-ATF3-DDIT3/CHOP 级联的作用。此外，CHAC1 作为 Notch 信号通路的负调节因子，通过弗林蛋白酶抑制 Notch 裂解，从而影响胚胎神经发生。这种抑制使Notch维持在不成熟、不活跃的状态，从而促进胚胎中的神经发生。

Human

E. coli

C-Strep

Q9BUX1 (K2-V222)

79094

Approximately 27.2 kDa.

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of 50 mM HEPES (pH 7.5), 200 mM NaCl, 20% glycerol, 1 mM DTT.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.