CLEC12A/MICL 蛋白, Cynomolgus (HEK293, His)

CLEC12A/MICL Protein is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. CLEC12A is a cell surface receptor known to regulate signaling cascades and facilitate the tyrosine phosphorylation of target MAP kinases. It interacts with PTPN6 and PTPN11, indicating its involvement in intricate cellular signaling processes. CLEC12A/MICL Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CLEC12A/MICL protein, expressed by HEK293 , with N-His labeled tag. The total length of CLEC12A/MICL Protein, Cynomolgus (HEK293, His) is 201 a.a., with molecular weight of 38-60 kDa.

C 型凝集素结构域家族 12 成员 A (CLEC12A) 是 C 型凝集素/C 型凝集素样结构域 (CTL/CTLD) 超家族的成员。CLEC12A 是一种II 型跨膜蛋白，在人体中骨髓细胞表达的，包括中性粒细胞、单核细胞、浆细胞样 BDCA2⁺ 和骨髓 CD1⁺c/CD19^- 树突状细胞。CLEC12A 是一种细胞表面受体，已知可调节信号级联并促进靶标 MAP 激酶的酪氨酸磷酸化。它与 PTPN6 和 PTPN11 相互作用，表明它参与复杂的细胞信号传导过程。此外，CLEC12A 可以通过与病原体衍生的晶体或抗原直接相互作用来调节对感染因子的炎症反应。它通过以刺激依赖性方式协同或拮抗包括TLR和CD40受体在内的多种受体的信号通路来调节细胞因子的合成。CLEC12A 还通过其内化抗原的能力参与适应性免疫，从而将抗原路由至主要组织相容性复合体 (MHC) 区室并呈递给 T 细胞^[1][2]。

Cynomolgus

HEK293

N-His

A0A2K5WXQ6 (H65-A265)

102143884  [NCBI]

38-60 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.