Clumping factor A 蛋白, S. aureus

Clustering factor A (ClfA) is a virulence-related cell surface-associated protein that plays a key role in bacterial pathogenicity. It promotes bacterial attachment exclusively to the gamma chain of human fibrinogen, demonstrating the specificity of its interaction with host proteins. Clumping factor A Protein, S. aureus is the recombinant Staphylococcus aureus-derived Clumping factor A protein, expressed by E. coli , with tag free. The total length of Clumping factor A Protein, S. aureus is 331 a.a., with molecular weight of ~36.1 kDa.

聚集因子 A (ClfA) 蛋白是一种细胞表面相关蛋白，在细菌毒力中发挥重要作用。这种蛋白质通过促进细菌专门附着在人纤维蛋白原的伽马链上，从而与细菌的致病性有关。通过选择性地与 γ 链结合，ClfA 促进细菌粘附于宿主组织，这是感染建立的关键步骤。此外，ClfA 会诱导细菌团块的形成，这可能会增强细菌的存活率并逃避宿主的免疫反应。多项研究表明，ClfA 是一种与毒力有关的细胞表面相关蛋白，特别强调了其在促进细菌附着于人纤维蛋白原的伽马链并诱导细菌团块形成方面的作用。

Staphylococcus aureus

E. coli

Tag Free

Q6GB45 (228G-558E)

/

GKDITNQLTNVTVGIDSGDTVYPHQAGYVKLNYGFSVPNSAVKGDTFKITVPKELNLNGVTSTAKVPPIMAGDQVLANGVIDSDGNVIYTFTDYVDTKENVTANITMPAYIDPENVTKTGNVTLTTGIGSTTANKTVLVDYEKYGKFYNLSIKGTIDQIDKTNNTYRQTIYVNPSGDNVIAPVLTGNLKPNTDSNALIDQQNTSIKVYKVDNAADLSESYFVNPENFEDVTNSVNITFPNPNQYKVEFNTPDDQITTPYIVVVNGHIDPNSKGDLALRSTLYGYDSRFVWRSMSWDNEVAFNNGSGSGDGIDKPVVPEQPDEPGEIEPIPE

Approximately 43 kDa. The reducing (R) protein migrat es as 43 kDa in SDS-PAGE may be due to relative Charge.

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against solution in 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.