2. 重组蛋白
  3. Immune Checkpoint Proteins CD Antigens Biotinylated Proteins
  4. Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins Dendritic Cell CD Proteins
  5. CTLA-4 CD152/CTLA-4
  6. CTLA-4 蛋白, Mouse (Biotinylated, HEK293, His)

CTLA-4 蛋白, Mouse (Biotinylated, HEK293, His)

目录号: HY-P75317
产品使用指南

CTLA-4 是一种关键的抑制性受体，在免疫调节中充当 T 细胞反应的主要负调节因子。其独特的性质是其与B7配体（CD80/CD86）的亲和力明显高于CD28。CTLA-4 蛋白, Mouse (Biotinylated, HEK293, His) 是重组的 CTLA-4 蛋白，由 HEK293 表达，带有 C-His 标签。CTLA-4 蛋白, Mouse (Biotinylated, HEK293, His) 全长 127 个氨基酸，分子量约为 ~15.3 kDa。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

CTLA-4 is a key inhibitory receptor that serves as a major negative regulator of T cell responses in immune regulation. Its unique property is that its affinity to B7 ligands (CD80/CD86) is significantly higher than that of CD28. CTLA-4 Protein, Mouse (Biotinylated, HEK293, His) is the recombinant mouse-derived CTLA-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of CTLA-4 Protein, Mouse (Biotinylated, HEK293, His) is 127 a.a., with molecular weight of ~15.3 kDa.
研究背景

CTLA-4 是一种关键的抑制性受体，在 T 细胞反应中充当主要负调节因子，在复杂的免疫调节网络中发挥影响力。这种调节功能源于 CTLA-4 的独特特性，与同源刺激辅助受体 CD28 相比，CTLA-4 对其天然 B7 家族配体 CD80 和 CD86 的亲和力显着增强。CTLA-4 的同二聚体结构通过二硫键错综复杂地连接，强调了其在免疫调节中作为分子哨兵的作用。从功能上讲，CTLA-4 与 CD80/B7-1 和 CD86/B7.2 紧密结合，竞争性地与这些配体结合，抑制 T 细胞激活并微调免疫反应。此外，CTLA-4 与 ICOSLG 相互作用，有助于其在免疫检查点通路中的多方面参与。
种属

Mouse
表达系统

HEK293
标签

C-His
蛋白编号

P09793 (E36-F162)
基因 ID
蛋白结构
N-term
CTLA-4 (E36-F162)
Accession # P09793
His
C-term
同用名
Cytotoxic T-lymphocyte associated protein 4; CTLA4; CD152
分子量

Approximately 15.3 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CTLA-4 Protein, Mouse (Biotinylated, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CTLA-4 Protein, Mouse (Biotinylated, HEK293, His)
目录号：
HY-P75317
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z