2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CXC Chemokines
  6. GRO-alpha
  7. GRO-alpha/CXCL1 蛋白, Human (His)

GRO-alpha/CXCL1 蛋白, Human (His)

目录号: HY-P700558
产品使用指南

GRO-alpha/CXCL1 蛋白吸引中性粒细胞，并可能通过对内皮细胞的自分泌作用导致炎症。GRO-α 的加工形式，包括 GRO-α(4-73)、GRO-α(5-73) 和 GRO-α(6-73)，其趋化活性比全长蛋白高 30 倍。GRO-alpha/CXCL1 蛋白, Human (His) 是重组的 GRO-alpha/CXCL1 蛋白，由 E. coli 表达，带有 N-6*His 标签。GRO-alpha/CXCL1 蛋白, Human (His) 全长 73 个氨基酸，分子量为 11.9 kDa。

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描述

GRO-alpha/CXCL1 protein attracts neutrophils and potentially contributes to inflammation through autocrine effects on endothelial cells. Processed forms of GRO-alpha, including GRO-alpha(4-73), GRO-alpha(5-73), and GRO-alpha(6-73), exhibit 30-fold greater chemotactic activity than the full-length protein. GRO-alpha/CXCL1 Protein, Human (His) is the recombinant human-derived GRO-alpha/CXCL1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GRO-alpha/CXCL1 Protein, Human (His) is 73 a.a., with molecular weight of 11.9 kDa.
研究背景

GRO-α/CXCL1 蛋白对中性粒细胞表现出趋化活性，并可能在炎症中发挥作用，以自分泌方式对内皮细胞发挥作用。体外研究表明，GRO-α 的加工形式，即 GRO-α(4-73)、GRO-α(5-73) 和 GRO-α(6-73)，显示出显着增强的趋化活性，为 30与全长蛋白质相比高倍。
种属

Human
表达系统

E. coli
标签

N-6*His
蛋白编号

P09341 (A35-N107)
基因 ID
蛋白结构
N-term
6*His
CXCL1 (A35-N107)
Accession # P09341
C-term
同用名
Growth-Regulated Alpha Protein; C-X-C Motif Chemokine 1; GRO-Alpha(1-73); Melanoma Growth Stimulatory Activity; MGSA; Neutrophil-Activating Protein 3; NAP-3; CXCL1; GRO; GRO1; GROA; MGSA; SCYB1
氨基酸序列

ASVATELRCQCLQTLQGIHPKNIQSVNVKSPGPHCAQTEVIATLKNGRKACLNPASPIVKKIIEKMLNSDKSN

分子量

11.9 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

GRO-alpha/CXCL1 Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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