2. 重组蛋白
  3. Cytokines and Growth Factors CD Antigens Receptor Proteins Enzymes & Regulators
  4. FGF Family Stem Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. FGFR-1/CD331 FGFR
  6. FGFR-1
  7. FGFR-1 beta (IIIb) 蛋白, Human (HEK293, Fc)

FGFR-1 beta (IIIb) 蛋白, Human (HEK293, Fc)

目录号: HY-P75765
产品使用指南

FGFR-1 beta 是 FGFR 家族的成员，与成纤维细胞生长因子相互作用并调节有丝分裂和分化。它特异性结合酸性和碱性成纤维细胞生长因子，并参与肢体诱导。该基因的突变与多种综合症和疾病有关。涉及该基因的染色体畸变与干细胞骨髓增殖性疾病和干细胞白血病淋巴瘤综合征有关。FGFR-1β 在多种组织中表达，包括卵巢和脂肪。FGFR-1 beta (IIIb) 蛋白, Human (HEK293, Fc) 是重组的蛋白二聚体复合物，包含 FGFR-1 beta (IIIb) 蛋白，由 HEK293 表达，带有 C-hFc 标签。FGFR-1 beta (IIIb) 蛋白, Human (HEK293, Fc)，分子量为 76-106 kDa。

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描述

FGFR-1 beta, a member of the FGFR family, interacts with fibroblast growth factors and regulates mitogenesis and differentiation. It specifically binds to acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene are associated with several syndromes and disorders. Chromosomal aberrations involving this gene are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. FGFR-1 beta is expressed in various tissues, including the ovary and fat. FGFR-1 beta (IIIb) Protein, Human (HEK293, Fc) is a recombinant protein dimer complex containing human-derived FGFR-1 beta, expressed by HEK293, with C-hFc labeled tag. FGFR-1 beta (IIIb) Protein, Human (HEK293, Fc), has molecular weight of 76-106 kDa.
研究背景

FGFR-1 β 蛋白是成纤维细胞生长因子受体 (FGFR) 家族中高度保守的成员，与其他成员具有相似的氨基酸序列。FGFR 家族成员对配体表现出不同的亲和力，并分布在各种组织中。全长蛋白质由具有三个免疫球蛋白样结构域的胞外区、疏水性跨膜片段和胞质酪氨酸激酶结构域组成。细胞外部分与成纤维细胞生长因子相互作用，启动调节有丝分裂和分化的下游信号。FGFR-1 β 特异性结合酸性和碱性成纤维细胞生长因子，并在肢体诱导中发挥作用。该基因的突变与多种综合征和疾病有关，包括 Pfeiffer 综合征、Jackson-Weiss 综合征、Antley-Bixler 综合征、骨发育不良和常染色体显性卡尔曼综合征 2。涉及该基因的染色体畸变与干细胞骨髓增殖性疾病和干细胞白血病淋巴瘤综合征。编码不同蛋白质亚型的各种可变剪接变体已被鉴定，尽管并非所有变体都已被完全表征。FGFR-1 β 蛋白在多种组织中普遍表达，包括卵巢、脂肪和 25 种其他组织。
种属

Human
表达系统

HEK293
标签

C-hFc
蛋白编号

NP_075594 (M1-K221&A270-E285)& AAB19502 (H1-P47)
基因 ID
同用名
Fibroblast growth factor receptor 1; FGFR-1; FGF R1b; FGFR1 beta
分子量

76-106 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

FGFR-1 beta (IIIb) Protein, Human (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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