1. 重组蛋白
  2. CD Antigens Enzymes & Regulators Fluorescent-labeled Recombinant Proteins
  3. Stem Cell CD Proteins Dendritic Cell CD Proteins Protein Tyrosine Kinases
  4. Flt-3/CD135 Flt-3
  5. FITC-Labeled FLT3 蛋白, Human (HEK293, Fc)

FITC-Labeled FLT3 蛋白, Human (HEK293, Fc)

目录号: HY-P701290
产品使用指南

FLT3 是一种酪氨酸蛋白激酶受体,可调节造血祖细胞和树突状细胞的分化、增殖和存活。它磷酸化下游效应器,例如 SHC1 和 AKT1,激活涉及 MTOR、RAS 和 MAP 激酶的信号级联。FITC-Labeled FLT3 蛋白, Human (HEK293, Fc) 是重组的 FITC 标记的 FLT3 蛋白,由 HEK293 表达,带有 Fc 标签。FITC-Labeled FLT3 蛋白, Human (HEK293, Fc) 全长 517 个氨基酸,分子量分别为 110-130 kDa & 250 kDa。

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1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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描述

FLT3 is a tyrosine-protein kinase receptor that regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and dendritic cells. It phosphorylates downstream effectors such as SHC1 and AKT1, activating signaling cascades involving MTOR, RAS, and MAP kinases. FITC-Labeled FLT3 Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled FLT3 protein, expressed by HEK293 , with Fc labeled tag. The total length of FITC-Labeled FLT3 Protein, Human (HEK293, Fc) is 517 a.a., with molecular weight of 110-130 kDa & 250 kDa, respectively.

研究背景

FLT3 是一种酪氨酸蛋白激酶,作为细胞因子 FLT3LG 的细胞表面受体发挥作用,对造血祖细胞和树突状细胞的分化、增殖和存活进行调节控制。该受体促进各种下游效应子的磷酸化,包括 SHC1 和 AKT1,并激活涉及 MTOR、RAS、MAPK1/ERK2 和/或 MAPK3/ERK1 的信号级联。此外,它在 FES、FER、PTPN6/SHP、PTPN11/SHP-2、PLCG1 以及 STAT5A 和/或 STAT5B 的磷酸化中发挥关键作用。虽然野生型 FLT3 激活会导致 STAT5A 或 STAT5B 适度激活,但引起组成型激酶活性的突变会导致细胞增殖增强和细胞凋亡抵抗力增强,从而强调了其在促进异常信号传导途径中的作用。

种属

Human

表达系统

HEK293

标签

Fc

蛋白编号

P36888 (N27-S543)

基因 ID

2322

同用名
Flt-3; Flk-2; STK-1; CD135; FLK2; FLT-3
分子量

110-130 kDa&250 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
FITC-Labeled FLT3 Protein, Human (HEK293, Fc)
目录号:
HY-P701290
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