FITC-labeled HER3 蛋白, Human (HEK293, His)

HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. FITC-labeled HER3 Protein, Human (HEK293, His) is the recombinant human-derived FITC-labeled HER3 protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of FITC-labeled HER3 Protein, Human (HEK293, His) is 624 a.a., with molecular weight of 72-75 kDa.

HER3 是一种酪氨酸蛋白激酶，是神经调节蛋白的关键细胞表面受体。由神经调节蛋白-1 (NRG1) 激活，配体结合增强酪氨酸残基的磷酸化，并促进其与磷脂酰肌醇 3-激酶 p85 亚基的相互作用。此外，有证据表明 CSPG5 可以激活。HER3 错综复杂地参与骨髓细胞分化的调节，突出了其在对正常发育和功能至关重要的细胞过程中的关键作用。

Human

HEK293

C-His;C-Avi

P21860 (S20-T643)

2065

72-75 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from 0.22 μm filtered solution of PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.