HDAC4 蛋白, Human (sf9)

The HDAC4 protein deacetylates core histones, thereby affecting transcription, cell cycle, and development. During muscle maturation, HDAC4 interacts with myocyte enhancer factors (MEF2A, MEF2C, and MEF2D). HDAC4 Protein, Human (sf9) is the recombinant human-derived HDAC4 protein, expressed by Sf9 insect cells , with tag free. The total length of HDAC4 Protein, Human (sf9) is 473 a.a., with molecular weight of ~51 kDa.

HDAC4 蛋白在核心组蛋白（H2A、H2B、H3 和 H4）N 端区域赖氨酸残基的脱乙酰化中发挥着至关重要的作用，有助于表观遗传抑制，而表观遗传抑制是重要细胞过程的基础，包括转录调控、细胞周期进展和发展事件。组蛋白脱乙酰酶（包括 HDAC4）在大型多蛋白复合物中发挥作用，协调这些复杂的调节机制。具体来说，HDAC4 通过与肌细胞增强因子（MEF2A、MEF2C 和 MEF2D）相互作用参与肌肉成熟。此外，HDAC4 在 MTA1 介导的乳腺癌 ESR1 表达的表观遗传调控中发挥着关键作用。值得注意的是，HDAC4 在“Lys-77”处使 HSPA1A 和 HSPA1B 去乙酰化，导致它们优先与辅助伴侣 STUB1 结合，证明该蛋白质在细胞过程和分子相互作用中具有多样化和微妙的参与。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

Sf9 insect cells

Tag Free

P56524 (M612-L1084)

9759  [NCBI]

Approximately 51 kDa

Greater than 90% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 10% Glycerol.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.