2. 重组蛋白
  3. CD Antigens Receptor Proteins
  4. Erythrocyte CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  5. ICAM-4/CD242 Immunoglobulin-like Cell Adhesion Molecules
  6. Intercellular Adhesion Molecule 4 (ICAM-4)
  7. ICAM-4 蛋白, Human (HEK293, Fc)

ICAM-4 蛋白, Human (HEK293, Fc)

目录号: HY-P76392
产品使用指南

Intercellular adhesion molecule 4 isoform 3 表达于红细胞、红系前体细胞和其他血细胞 (包括 T 和 B 细胞)上。Intercellular adhesion molecule 4 isoform 3 属于免疫球蛋白超家族 (IgSF)，由 5 个成员组成，分别命名为 ICAM1-ICAM5。Intercellular adhesion molecule 4 isoform 3 是 Rh 多肽 (RhD 和 RhCE) 和 Rh 相关糖蛋白 (RhAG) 组成的Rh大分子复合体的一部分。Intercellular adhesion molecule 4 isoform 3 维持红细胞表面和血管内皮之间的密切接触，也在各种正常和病理状态中发挥作用，包括红细胞生成和镰状细胞病疼痛危象期间的微血管闭塞。ICAM-4 蛋白, Human (HEK293, Fc) 是重组的 ICAM-4 蛋白，由 HEK293 表达，带有 C-hFc 标签。ICAM-4 蛋白, Human (HEK293, Fc) 全长 250 个氨基酸，分子量分别约为 ~55 & 33 KDa。

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描述

Intercellular adhesion molecule 4 isoform 3 is expressed on RBCs, erythroid precursor cells, and on other blood cells including T and B cells. Intercellular adhesion molecule 4 isoform 3 belongs to the immunoglobulin superfamily (IgSF) consisting of five members designated ICAM1 to ICAM5. Intercellular adhesion molecule 4 isoform 3 is part of the Rh macromolecular complex consisting of Rh polypeptides (RhD and RhCE) and the Rh-associated glycoprotein (RhAG). Intercellular adhesion molecule 4 isoform 3 maintains close contact between the RBC surface and vascular endothelium and also plays a role in various normal and pathologic conditions, including erythropoiesis and microvascular occlusions during painful crises of sickle cell disease, respectively. ICAM-4 Protein, Human (HEK293, Fc) is the recombinant human-derived ICAM-4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ICAM-4 Protein, Human (HEK293, Fc) is 250 a.a., with molecular weight of ~55 & 33 KDa, respectively.
研究背景

Intercellular adhesion molecule 4 isoform 3 表达于红细胞、红系前体细胞和其他血细胞 (包括 T 和 B 细胞)上。Intercellular adhesion molecule 4 isoform 3 属于免疫球蛋白超家族 (IgSF)，由 5 个成员组成，分别命名为 ICAM1-ICAM5。Intercellular adhesion molecule 4 isoform 3 是 Rh 多肽 (RhD 和 RhCE) 和 Rh 相关糖蛋白 (RhAG) 组成的Rh大分子复合体的一部分。Intercellular adhesion molecule 4 isoform 3 维持红细胞表面和血管内皮之间的密切接触，也在各种正常和病理状态中发挥作用，包括红细胞生成和镰状细胞病疼痛危象期间的微血管闭塞。Intercellular adhesion molecule 4 isoform 3 编码的 Landsteiner-Wiener (LW) 血型抗原属于免疫球蛋白 (Ig) 超家族，与细胞间黏附分子 (ICAM) 蛋白家族有相似之处。Intercellular adhesion molecule 4 isoform 3 包含 2 个 ig 样 c2 型结构域并与白细胞黏附 LFA-1 蛋白结合[1][2][3]。
种属

Human
表达系统

HEK293
标签

C-hFc
蛋白编号

U5U6P8 (A23-G272)
基因 ID
蛋白结构
N-term
ICAM-4 (A23-G272)
Accession # U5U6P8
hFc
C-term
同用名
Intercellular adhesion molecule 4 isoform 3; ICAM4; CD242
分子量

Approximately 55&33 kDa.
纯度

Greater than 85% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

ICAM-4 Protein, Human (HEK293, Fc) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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