IGF-I R 蛋白, Cynomolgus (HEK293, His)

The IGF-I R protein is a receptor tyrosine kinase that mediates the effects of insulin-like growth factor 1 (IGF1) and has high affinity for IGF1. Upon ligand binding, IGF1R is activated, leading to autophosphorylation and tyrosine phosphorylation of substrates, including IRS1/2, Shc, and 14-3-3 proteins. IGF-I R Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IGF-I R protein, expressed by HEK293 , with C-His labeled tag. The total length of IGF-I R Protein, Cynomolgus (HEK293, His) is 878 a.a., with molecular weight (glycosylation form) of 48-58 kDa (β subunit) & 100-115 kDa (α subunit) & 130-150 kDa, respectively.

IGF-I R 蛋白是一种受体酪氨酸激酶，充当胰岛素样生长因子 1 (IGF1) 作用的介质。它对 IGF1 具有高亲和力，对 IGF2 和胰岛素 (INS) 具有较低亲和力。IGF1R 的激活在控制细胞生长和存活中发挥着关键作用，对肿瘤转化和恶性细胞的存活具有重要影响。配体结合后，受体激酶被激活，导致多种底物的自身磷酸化和酪氨酸磷酸化，包括胰岛素受体底物 (IRS1/2)、Shc 和 14-3-3 蛋白。IRS 蛋白的磷酸化启动两个主要信号传导途径：PI3K-AKT/PKB 途径和 Ras-MAPK 途径。MAPK 途径的激活可增强细胞增殖，而 PI3K 途径的激活可抑制细胞凋亡并刺激蛋白质合成。此外，IGF1R 通过 Janus 激酶/信号转导器和转录激活剂 (JAK/STAT) 发出信号，其中 JAK 蛋白的磷酸化可以激活 STAT 蛋白，特别是 STAT3，从而促进 IGF1R 的转化活性。此外，IGF1R 激活 JNK 激酶并对 JNK 激活发挥抑制作用。当与 INSR 形成杂合受体时，IGF1R 与 IGF1 结合。

Cynomolgus

HEK293

C-His

G7P9I7 (E31-N908)

102130142  [NCBI]

Due to glycosylation, the protein migrates to 48-58 kDa (β subunit) and 100-115 kDa (α subunit) and 130-150 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.