IL-1 beta 蛋白, Cynomolgus (C-His)

IL-1 beta Protein, a potent pro-inflammatory cytokine and endogenous pyrogen, induces diverse responses, including prostaglandin synthesis, neutrophil and T-cell activation, B-cell activation, and fibroblast proliferation. It promotes Th17 differentiation, synergizes with IL12 for Th1 IFNG synthesis, and contributes to angiogenesis by inducing VEGF production with TNF and IL6. Involved in pyroptosis, its mature form is released through the GSDMD pore. Existing as a monomer, IL-1 beta Protein interacts with MEFV. IL-1 beta Protein, Cynomolgus (C-His) is the recombinant cynomolgus-derived IL-1 beta protein, expressed by E. coli, with C-His labeled tag. The total length of IL-1 beta Protein, Cynomolgus (C-His) is 152 a.a., with molecular weight of 18.33 kDa.

IL-1 β 蛋白是一种有效的促炎细胞因子，最初被发现是一种主要的内源性热原。它诱导前列腺素合成、中性粒细胞激活、T 细胞激活和细胞因子产生、B 细胞激活和抗体产生、以及成纤维细胞增殖和胶原蛋白产生。IL-1 beta 蛋白还促进 T 细胞的 Th17 分化，并与 IL12 协同诱导 Th1 细胞合成 IFNG。此外，它通过与 TNF 和 IL6 协同诱导 VEGF 产生，在血管生成中发挥作用。IL-1 β 蛋白参与焦亡下游炎症的转导，其成熟形式通过gasdermin-D (GSDMD) 孔特异性释放到细胞外环境中。它以单体形式存在并与 MEFV 相互作用。

Cynomolgus

E. coli

C-His

A0A2K5VDC7 (A117-S268)

/

18.33 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.