IL-1 Rrp2/IL-1 R6 蛋白, Cynomolgus (HEK293, His)

L-36R is a member of the IL-1 receptor family that contains six receptor proteins that form four signaling complexes: IL-1RI, IL-18R, IL-33R, and IL-36R, and two decoy receptors and two negative regulators. IL-36R is a heterodimer that consists of a receptor subunit named IL-1Rrp2 (IL-1RL2) and a co-receptor subunit Interleukin-1 receptor accessory protein, IL-1RAcP. The receptor can recognize three different agonists, IL-36α, IL-36β, and IL-36γ (also known as IL-1F6, IL-1F8, and IL-1F9), to induce the expression of inflammatory cytokines^[1][2]. IL-1 Rrp2/IL-1 R6 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-1 Rrp2/IL-1 R6 protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-1 Rrp2/IL-1 R6 Protein, Cynomolgus (HEK293, His) is 316 a.a., with molecular weight of 60-70 kDa.

IL-1Rrp2 作为配体结合 IL-1F9，这种结合导致转录因子 NF-kB 的激活。IL-1家族有11个成员和IL-1受体家族成员有9个。新型 IL-1 细胞因子 IL-1F6、IL-1F8 和 IL-1F9 (最近分别更名为 IL-36α、IL-36β 和 IL-36γ) 已被证明通过 IL-1 受体相关蛋白 2 (IL- 1Rrp2，最近更名为 IL-36R)。IL-1Rrp2 表达受到经典 (IL-1β) 和新型 IL-1 细胞因子 (IL-1F8 和 IL-1F9) 的调节。大鼠和人 cDNA 编码的 IL-1Rrp2 蛋白均为 561 个氨基酸长，与 IL-1 1 型和 2 型受体的总体同一性分别为 42% 和 26%。通过 IL-1Rrp2 阻断信号传导的药物可能是治疗银屑病的有用工具^[1]。

Cynomolgus

HEK293

C-His

EHH61702 (D20-R335)

/

60-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.