IL-2R alpha 蛋白, Human (HEK293, His)

IL-2R alpha protein is the receptor for interleukin 2 and plays a crucial role in immune tolerance by regulating the activity of regulatory T cells (TREG). These TREGs are responsible for inhibiting the activation and expansion of autoreactive T cells. IL-2R alpha Protein, Human (HEK293, His) is the recombinant human-derived IL-2R alpha protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IL-2R alpha Protein, Human (HEK293, His) is 192 a.a., with molecular weight of ~44.0 kDa.

IL-2R α 是白介素 2 的一种受体，通过调节调节性 T 细胞 (TREG) 的活性，在免疫耐受的调节中发挥着关键作用。TREG 的作用是抑制自身反应性 T 细胞的激活和扩张，有助于免疫稳态。该受体以三种不同的形式存在：高亲和力二聚体、中等亲和力单体（β亚基）和低亲和力单体（α亚基）。高亲和力和中等亲和力形式均可与 γ 亚基结合，突出了 IL-2R 在介导免疫反应中的多方面性质。

2 μg/mL (100 μL/well) of immobilized Human IL-2RA-His can bind Human IL-2-His-Avi with an ED₅₀ value of 4.07 ng/mL.

Human

HEK293

C-6*His

P01589 (E22-C213)

3559  [NCBI]

ELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKSGSLYMLCTGNSSHSSWDNQCQCTSSATRNTTKQVTPQPEEQKERKTTEMQSPMQPVDQASLPGHCREPPPWENEATERIYHFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQPQLICTGEMETSQFPGEEKPQASPEGRPESETSC

Approximately 44.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 10 mM HEPES, 50 mM NaCl, pH 7.2.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.