KCNJ16 蛋白, Human (Cell-Free, His)

The KCNJ16 protein is a member of inwardly rectifying potassium channels, which facilitates the influx of potassium into cells. Extracellular potassium concentration modulates voltage dependence, resulting in a positive voltage shift. KCNJ16 Protein, Human (Cell-Free, His) is the recombinant human-derived KCNJ16 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of KCNJ16 Protein, Human (Cell-Free, His) is 418 a.a., with molecular weight of 50.8 kDa.

KCNJ16 蛋白属于内向整流钾通道家族，表现出一种独特的特性，有利于钾流入细胞而不是流出。这些通道的电压依赖性受到细胞外钾浓度的调节，导致随着外部钾水平升高而向更正的电压转变。内部镁主要通过阻止外向电流来促进内向整流。值得注意的是，KCNJ16 参与体液和 pH 平衡的调节。在肾脏中，它与 KCNJ10 一起在介导远端肾小管基底外侧 K(+) 循环中发挥着至关重要的作用，这是 Na(+) 重吸收所必需的过程。与 Kir4.1/KCNJ10 形成异二聚体对于 KCNJ16 定位至肾细胞基底外侧膜是不可或缺的。此外，作为 KCNJ10 的异二聚体，KCNJ16 可能与 MAGI1 相互作用，可能促进肾细胞基底外侧膜钾通道的表达。此外，有可能与 Kir2.1/KCNJ2 形成异二聚体。

Human

E. coli Cell-free

N-10*His

Q9NPI9 (M1-M418)

3773

MSYYGSSYHIINADAKYPGYPPEHIIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYVVDIFTTLVDTKWRHMFVIFSLSYILSWLIFGSVFWLIAFHHGDLLNDPDITPCVDNVHSFTGAFLFSLETQTTIGYGYRCVTEECSVAVLMVILQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYTEDSEGRMTMAFKDLKLVNDQIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYVPREILWGHRFNDVLEVKRKYYKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLHIEKAPPVRESCTSDTKARRRSFSAVAIVSSCENPEETTTSATHEYRETPYQKALLTLNRISVESQM

50.8 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.