2. 重组蛋白
  3. CD Antigens Receptor Proteins
  4. Macrophage CD Proteins Monocyte CD Proteins Stem Cell CD Proteins Platelet CD Proteins Erythrocyte CD Proteins Dendritic Cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  5. CD31/PECAM-1 IREM-1/CD300f Immunoglobulin-like Cell Adhesion Molecules
  6. CD31/PECAM-1 蛋白, Human (HEK293, Fc)

CD31/PECAM-1 蛋白, Human (HEK293, Fc)

目录号: HY-P70988
产品使用指南

CD31/PECAM-1 是一种细胞-细胞粘附蛋白。CD31/PECAM-1 可调节内皮细胞中缓激素受体 BDKRB2 的激活和高渗休克诱导的 ERK1/2 活化以及诱导对动脉粥样硬化的易感性。CD31/PECAM-1 介导与内皮细胞的粘附，通过形成新的内皮细胞管调节肿瘤生长。CD31/PECAM-1 蛋白, Human (HEK293, Fc) 是重组的 CD31/PECAM-1 蛋白，由 HEK293 表达，带有 C-hFc 标签。CD31/PECAM-1 蛋白, Human (HEK293, Fc) 全长 574 个氨基酸，分子量为 110-130 kDa。

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描述

CD31/PECAM-1 is a cell-cell adhesion protein. CD31/PECAM-1 regulates the activation of the slow hormone receptor BDKRB2 in endothelial cells and the activation of ERK1/2 induced by hypertonic shock and induces susceptibility to atherosclerosis. CD31/PECAM-1 mediates adhesion to endothelial cells and regulates tumor growth by forming new endothelial cell tubes. CD31/PECAM-1 Protein, Human (HEK293, Fc) is the recombinant human-derived CD31/PECAM-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD31/PECAM-1 Protein, Human (HEK293, Fc) is 574 a.a., with molecular weight of 110-130 kDa.
研究背景

Platelet endothelial cell adhesion molecule (PECAM1) 也被称为 CD31 ，是一种细胞-细胞粘附蛋白。CD31/PECAM-1 通常存在于内皮细胞、血小板、巨噬细胞和库普弗细胞、粒细胞、淋巴细胞 (T 细胞、B 细胞和NK 细胞)、巨核细胞和破骨细胞中。CD31/PECAM-1 可调节缓激素受体 BDKRB2 激活、内皮细胞中缓激素和高渗休克诱导的 ERK1/2 活化以及诱导对动脉粥样硬化的易感性。CD31/PECAM-1 介导与内皮细胞的粘附，通过形成新的内皮细胞管调节肿瘤生长。
种属

Human
表达系统

HEK293
标签

C-hFc
蛋白编号

AAH22512.1 (Q28-K601)
基因 ID
蛋白结构
N-term
CD31 (Q28-K601)
Accession # AAH22512.1
hFc
C-term
同用名
Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA; PECA1; CD31; PECAM1
氨基酸序列

QENSFTINSVDMKSLPDWTVQNGKNLTLQCFADVSTTSHVKPQHQMLFYKDDVLFYNISSMKSTESYFIPEVRIYDSGTYKCTVIVNNKEKTTAEYQVLVEGVPSPRVTLDKKEAIQGGIVRVNCSVPEEKAPIHFTIEKLELNEKMVKLKREKNSRDQNFVILEFPVEEQDRVLSFRCQARIISGIHMQTSESTKSELVTVTESFSTPKFHISPTGMIMEGAQLHIKCTIQVTHLAQEFPEIIIQKDKAIVAHNRHGNKAVYSVMAMVEHSGNYTCKVESSRISKVSSIVVNITELFSKPELESSFTHLDQGERLNLSCSIPGAPPANFTIQKEDTIVSQTQDFTKIASKSDSGTYICTAGIDKVVKKSNTVQIVVCEMLSQPRISYDAQFEVIKGQTIEVRCESISGTLPISYQLLKTSKVLENSTKNSNDPAVFKDNPTEDVEYQCVADNCHSHAKMLSEVLRVKVIAPVDEVQISILSSKVVESGEDIVLQCAVNEGSGPITYKFYREKEGKPFYQMTSNATQAFWTKQKANKEQEGEYYCTAFNRANHASSVPRSKILTVRVILAPWKK

分子量

110-130 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CD31/PECAM-1 Protein, Human (HEK293, Fc) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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