PPAR gamma 蛋白, Human (C-His)

PPAR gamma Protein, a nuclear receptor, binds peroxisome proliferators, activating upon ligand binding to specific PPRE on DNA. It modulates target gene transcription, controlling fatty acid metabolism. Essential in adipocyte differentiation and glucose homeostasis, PPAR gamma suppresses NF-kappa-B-mediated inflammation, regulates BMAL1 in cardiovascular circadian rhythms, and modulates immune responses to M.tuberculosis by influencing MAPK p38 phosphorylation and IL-6 production. PPAR gamma Protein, Human (C-His) is the recombinant human-derived PPAR gamma protein, expressed by E. coli, with C-6*His labeled tag. The total length of PPAR gamma Protein, Human (C-His) is 266 a.a., with molecular weight of ~30 kDa.

PPAR γ 蛋白是一种核受体，可与降血脂药物和脂肪酸等过氧化物酶体增殖物结合。配体激活后，核受体与 DNA 上的特定 PPAR 反应元件 (PPRE) 相互作用，调节酰基辅酶 A 氧化酶等靶基因的转录，从而控制脂肪酸的过氧化物酶体 β 氧化途径。它作为脂肪细胞分化和葡萄糖稳态的关键调节剂发挥着关键作用。此外，PPAR γ 通过抑制 NF-κ-B 介导的促炎症反应，充当肠道稳态的关键调节剂。在心血管昼夜节律的背景下，它调节血管中 BMAL1 的转录。此外，为了应对微生物感染，特别是结核分枝杆菌或其脂蛋白 LpqH 治疗，PPAR γ 调节 MAPK p38 的磷酸化和 IL-6 的产生，表明其参与微生物挑战期间的免疫反应。

Data is not available.

Human

E. coli

C-6*His

P37231 (D238-D503)

5468  [NCBI]

DLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKD

Approximately 30 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of sterile 50mM Tris, 300mM NaCl, 500 mM arginine, pH 8.0, 10% Glycerol.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.