2. 重组蛋白
  3. Enzymes & Regulators
  4. Transferases (EC 2)
  5. RCK 蛋白, Human (His)

RCK 蛋白, Human (His)

目录号: HY-P701764
产品使用指南

MAP3K19 是一类在细胞内参与信号传导的蛋白激酶。MAP3K19 能直接激活 ERK 和 JNK 通路，并在维持 KRAS 突变型肺癌细胞的生存中发挥重要作用。此外，MAP3K19 还调节哮喘患者中的过敏性气道炎症，它能抑制 TWEAK 刺激的气道上皮反应，包括粘附因子减弱和 RANTES 产生，并抑制哮喘小鼠模型中的过敏性气道炎症。RCK 蛋白, Human (His) 是重组的 RCK 蛋白，由 E. coli 表达，带有 N-6*His 标签。RCK 蛋白, Human (His) 全长 305 个氨基酸。

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100 μg   询价  

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描述

MAP3K19 is a protein kinase involved in intracellular signaling. MAP3K19 can directly activate the ERK and JNK pathways and plays an important role in maintaining the survival of KRAS-mutant lung cancer cells. In addition, MAP3K19 also regulates allergic airway inflammation in patients with asthma by inhibiting airway epithelial responses stimulated by TWEAK, including reduced adhesion factors and production of RANTES, and suppressing allergic airway inflammation in a mouse model of asthma. RCK Protein, Human (His) is the recombinant human-derived RCK protein, expressed by E. coli , with N-6*His labeled tag. The total length of RCK Protein, Human (His) is 305 a.a., .
研究背景

MAP3K19 能直接激活 ERK 和 JNK 通路，并在维持 KRAS 突变型肺癌细胞的生存中发挥重要作用[1]。
MAP3K19 在调节 TGF-β 诱导的 Smad 信号传导和基因表达中发挥作用[2]。
MAP3K19 能抑制 TWEAK 刺激的气道上皮反应，包括粘附因子减弱和 RANTES 产生，并抑制了哮喘小鼠模型中的过敏性气道炎症，表明 MAP3K19 调节哮喘患者中的过敏性气道炎症[3]。
种属

Human
表达系统

E. coli
标签

N-6*His
蛋白编号

Q56UN5 (Q1024-H1328)
基因 ID

80122
蛋白结构
N-term
6*His
RCK (Q1024-H1328)
Accession # Q56UN5
C-term
同用名
MAP3K19; Mitogen-activated protein kinase kinase kinase 19; Regulated in COPD; protein kinase; SPS1/STE20-related protein kinase YSK4
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

RCK Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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