2. 重组蛋白
  3. CAR-T related Proteins Receptor Proteins Enzymes & Regulators
  4. ROR1 Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. ROR family
  6. ROR1 蛋白, Mouse (HEK293, His)

ROR1 蛋白, Mouse (HEK293, His)

目录号: HY-P78032
产品使用指南

ROR1 蛋白在体外显示出最小的激酶活性，表明在体内不太可能发挥酪氨酸激酶的作用。它作为 WNT5A 受体发挥作用，激活 NFkB 信号传导并可能抑制 WNT3A 信号传导。此外，ROR1 在内耳中发挥着至关重要的作用，有助于螺旋神经节神经元对听毛细胞的神经支配。ROR1 蛋白, Mouse (HEK293, His) 是重组的 ROR1 蛋白，由 HEK293 表达，带有 C-His 标签。ROR1 蛋白, Mouse (HEK293, His) 全长 377 个氨基酸，分子量为 58-68 kDa。

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描述

ROR1 protein shows minimal kinase activity in vitro, indicating an improbable role as a tyrosine kinase in vivo. It functions as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Additionally, ROR1 plays a vital role in the inner ear, aiding the innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ROR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of ROR1 Protein, Mouse (HEK293, His) is 377 a.a., with molecular weight of 58-68 kDa.
研究背景

ROR1 蛋白在体外表现出非常低的激酶活性，表明在体内不太可能发挥酪氨酸激酶的作用。它作为配体 WNT5A 的受体，激活下游 NFkB 信号通路并可能抑制 WNT3A 介导的信号传导。值得注意的是，ROR1 在内耳中发挥着至关重要的作用，特别是在促进螺旋神经节神经元对听毛细胞的神经支配方面。
种属

Mouse
表达系统

HEK293
标签

C-His
蛋白编号

Q9Z139 (Q30-Y406)
基因 ID

26563  [NCBI]
蛋白结构
N-term
ROR1 (Q30-Y406)
Accession # Q9Z139
His
C-term
同用名
ROR1; NTRKR1; dJ537F10.1
分子量

58-68 kDa
纯度

Greater than 95% as determined by Tris-Bis PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

ROR1 Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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