TFF3 蛋白, Human (HEK293, His)

Trefoil factor 3 (TFF3) is a small peptide (59 amino acids; 7 kDa) that is a member of the trefoil family and a stable secretory protein expressed in gastrointestinal mucosa, playing a role in restitution and regeneration of epithelia. The mode of action of Tff3 ranges from a simple increase in mucous viscosity, cytoprotection, and antiapoptotic and chemotactic effects to more complex immune regulatory functions, and has a strong association with tumorigenesis. TFF3 Protein, Human (HEK293, His) is the recombinant human-derived TFF3 protein, expressed by HEK293 , with C-His labeled tag. The total length of TFF3 Protein, Human (HEK293, His) is 59 a.a., with molecular weight of ~8 kDa.

三叶因子3 (TFF3) 是一个小肽 (59 个氨基酸;7 kDa)，是三叶家族的成员，其特征是具有至少一个三叶基序的拷贝，这是一个包含三个具有三环结构的保守二硫化物的 40 个氨基酸结构域。TFF3 是一种稳定的分泌蛋白，表达于胃肠道黏膜，参与上皮细胞的修复 (细胞迁移愈合浅表病变) 和再生 (分化增殖修复)，参与肠黏膜的维持和修复，促进愈合过程中上皮细胞的移动。Tff3 的作用模式从简单的增加黏液粘度、细胞保护、抗凋亡和趋化作用到更复杂的免疫调节功能。Tff3 的表达模式在各种肿瘤中发生改变，这意味着它与肿瘤发生密切相关。Tff3 存在于血液和各种其他器官中，包括肝脏、大脑、胰腺和淋巴组织^[1][2][3]。

Human

HEK293

C-His

Q07654 (E22-F80)

7033  [NCBI]

Approximately 8 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.