2. 重组蛋白
  3. Cytokines and Growth Factors
  4. TNF Superfamily
  5. TNF Superfamily Ligands
  6. TL1A
  7. TL1A/TNFSF15 蛋白, Human (O95150-2, HEK293, His)

TL1A/TNFSF15 蛋白, Human (O95150-2, HEK293, His)

目录号: HY-P71981
产品使用指南

TL1A/TNFSF15 蛋白是 TNFRSF25 和 TNFRSF6B 的受体，可激活 NF-kappa-B 并促进 caspase 激活，从而导致细胞凋亡。它还在体外抑制血管内皮生长和血管生成。作为同源三聚体，它在多种细胞过程中发挥着至关重要的作用，包括免疫反应和细胞凋亡调节。TL1A/TNFSF15 蛋白, Human (O95150-2, HEK293, His) 是重组的 TL1A/TNFSF15 蛋白，由 HEK293 表达，带有 标签。TL1A/TNFSF15 蛋白, Human (O95150-2, HEK293, His) 全长 192 个氨基酸，分子量约为 ~33 kDa。

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描述

TL1A/TNFSF15 Protein, the receptor for TNFRSF25 and TNFRSF6B, activates NF-kappa-B and promotes caspase activation, leading to apoptosis. It also inhibits vascular endothelial growth and angiogenesis in vitro. Operating as a homotrimer, it plays a crucial role in diverse cellular processes, including immune response and apoptosis regulation. TL1A/TNFSF15 Protein, Human (O95150-2, HEK293, His) is the recombinant human-derived TL1A/TNFSF15 protein, expressed by HEK293 , with labeled tag. The total length of TL1A/TNFSF15 Protein, Human (O95150-2, HEK293, His) is 192 a.a., with molecular weight of ~33 kDa.
研究背景

TL1A/TNFSF15 蛋白作为 TNFRSF25 和 TNFRSF6B 的受体，促进 NF-κ-B 的激活，并促进 Caspases 的激活，导致细胞凋亡。此外，它在体外对血管内皮生长和血管生成具有抑制作用。该蛋白质作为同源三聚体发挥作用，强调了其在多种细胞过程中的作用，包括免疫反应和细胞凋亡调节。
种属

Human
表达系统

HEK293
标签

N-10*His
蛋白编号

O95150-2 (M1-L192)
基因 ID
蛋白结构
N-term
10*His
TL1A (M1-L192)
Accession # O95150-2
C-term
同用名
MGC129934; MGC129935; TL1 A; tl1; tl1a; tnf ligand related molecule 1; TNF ligand-related molecule 1; tnf superfamily ligand tl1a; TNF15_HUMAN; TNFSF15; Tumor necrosis factor ligand; superfamily member 15; Tumor necrosis factor ligand superfamily member 15; Tumor necrosis factor ligand superfamily member 15, secreted form; Vascular endothelial cell growth inhibitor; Vascular endothelial growth inhibitor 192a; Vascular endothelial growth inhibitor; vegi; VEGI192A
氨基酸序列

MQLTKGRLHFSHPLSHTKHISPFVTDAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL

分子量

Approximately 33 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

TL1A/TNFSF15 Protein, Human (O95150-2, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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