VEGF-DD 蛋白, Human (HEK293, His)

VEGF-DD protein is a potent growth factor in angiogenesis, lymphangiogenesis, and endothelial cell growth, playing a key role in stimulating cell proliferation, migration, and affecting vascular permeability. It may be involved in the formation of veins and lymphatic vasculature during embryogenesis, suggesting that it plays a key role in vascular development. VEGF-DD Protein, Human (HEK293, His) is the recombinant human-derived VEGF-DD protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VEGF-DD Protein, Human (HEK293, His) is 109 a.a., with molecular weight of ~18.0 kDa.

VEGF-DD 蛋白是一种在血管生成、淋巴管生成和内皮细胞生长中具有显着活性的生长因子，在刺激这些细胞的增殖和迁移方面发挥着关键作用，同时也影响血管通透性。它在胚胎发生过程中可能参与静脉和淋巴管系统的形成，这表明它在血管发育中发挥着关键作用。此外，VEGF-DD 可能有助于维持成人分化的淋巴内皮。该蛋白通过结合和激活 VEGFR-2 (KDR/FLK1) 和 VEGFR-3 (FLT4) 受体来实现这些效果。在结构上，VEGF-DD 以同二聚体形式存在，表现出非共价和反平行排列，突出了其在调节血管过程中的多方面作用，并强调了其在发育和成人血管生成和淋巴管生成中的重要性。

Human

HEK293

C-6*His

O43915 (F93-S201)

2277  [NCBI]

FYDIETLKVIDEEWQRTQCSPRETCVEVASELGKSTNTFFKPPCVNVFRCGGCCNEESLICMNTSTSYISKQLFEISVPLTSVPELVPVKVANHTGCKCLPTAPRHPYS

Approximately 18.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.