2. GPCR/G Protein
  3. GLP Receptor
  4. RG7697

RG7697 是胰高血糖素样肽受体 (GLP Receptor) 和葡萄糖依赖性促胰岛素多肽受体 (GIPR) 的双重激动剂，EC50 分别为 5 和 3 pM。RG7697 具有抗高血糖活性。

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RG7697 Chemical Structure

RG7697 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

RG7697 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RG7697 is a dual agonist for glucagon-like peptide receptor (GLP Receptor) and glucosedependent insulinotropic polypeptide receptor (GIPR), with EC50 of 5 and 3 pM, respectively. RG7697 exhibits antihyperglycemic property[1].

IC50 & Target

EC50: 3 pM (GIPR), 5 pM (GLP Receptor)
体内研究
(In Vivo)

RG7697 (3-30 nmol/kg，皮下注射，每天，共 7 天；或每两天一次，共 30 天) 促进胰岛素分泌和代谢，减少葡萄糖转移，并改善 C57BL/6 小鼠模型中饮食诱导的 2 型糖尿病和肥胖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet induced type 2 diabete and obesity in C57BL/6 mice[1]
Dosage: 3-30 nmol/kg
Administration: s.c., daily for 7 days or once every week for 30 days
Result: Reduced body weight, blood glucose and food intake.
Decreased intraperitoneal glucose tolerance, plasma insulin and cholesterol.
分子量

4473.04

Formula

C211H316N46O61
非同位 CAS

Sequence

Tyr-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Tyr-Leu-Asp-Lys-Gln-Ala-Ala-{Aib}-Glu-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-{Lys(C16 acid)}-NH2
Sequence Shortening

Y-{Aib}-EGTFTSDYSIYLDKQAA-{Aib}-EFVNWLLAGGPSSGAPPPS-{Lys(C16 acid)}-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RG7697 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RG7697RG 7697RG-7697GLP Receptortype 2 diabetesobesityC57BL/6 miceantihyperglycemicInhibitorinhibitorinhibit

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Inquiry Information

产品名称：
RG7697
目录号：
HY-P10271
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