1. Apoptosis Metabolic Enzyme/Protease
  2. Apoptosis Endogenous Metabolite
  3. Ompenaclid

Ompenaclid  (Synonyms: 胍基丙酸; RGX-202; 3-Guanidinopropionic acid)

目录号: HY-W015828 纯度: ≥98.0%
COA 产品使用指南

Ompenaclid (RGX-202) 是一种具有口服活性的 SLC6A8 转运蛋白抑制剂。Ompenaclid 在体外和体内均强烈抑制肌酸输入,降低细胞内磷酸肌酸和 ATP 水平,并诱导肿瘤凋亡 (apoptosis)。Ompenaclid 可用于肿瘤和杜氏肌营养不良症的研究。

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Ompenaclid Chemical Structure

Ompenaclid Chemical Structure

CAS No. : 353-09-3

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10 mM * 1 mL in Water ¥385
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50 mg ¥350
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100 mg ¥520
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Customer Review

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ompenaclid (RGX-202) is an oral small-molecule SLC6A8 transporter inhibitor. Ompenaclid robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. Ompenaclid can be used for the research of cancer and duchenne muscular dystrophy[1][2].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Ompenaclid (RGX-202; 10 μM; 96 hours) reduces cell growth, and reveals a nearly complete depletion of phosphocreatine (>99%), greater than 79% reduction in cellular creatine and a substantial (46%) reduction in intracellular ATP levels relative to control cells in hypoxia[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Ompenaclid (RGX-202; 800 mg/kg; p.o. for 35 days) reduces UN-KPC-961 pancreatic tumoral creatine levels in B6129SF1/J mice[1].
? Ompenaclid (approximately 650 mg/kg; i.p. daily for 14 days) treatment reduces Lvm3b cells liver metastatic colonization by eightfold in NOD-SCID mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: UN-KPC-961 pancreatic tumor-bearing B6129SF1/J mice[1]
Dosage: 800 mg/kg
Administration: p.o. for 35 days
Result: Suppressed tumoral d3-creatine import by 50% at 800 mg/kg.
Animal Model: 6- to 9-week-old C57BL/6J male wild-type mice[1]
Dosage: 100, 250, 500 mg/KG in sterile 0.9% NaCl
Administration: p.o. for 35 days
Result: Inhibited tissue uptake of d3-creatine in a dose-dependent manner by up to 75% at 500 mg/kg.
Clinical Trial
分子量

131.14

Formula

C4H9N3O2

CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验: 

H2O 中的溶解度 : ≥ 50 mg/mL (381.27 mM)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 7.6254 mL 38.1272 mL 76.2544 mL
5 mM 1.5251 mL 7.6254 mL 15.2509 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥98.0%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.6254 mL 38.1272 mL 76.2544 mL 190.6360 mL
5 mM 1.5251 mL 7.6254 mL 15.2509 mL 38.1272 mL
10 mM 0.7625 mL 3.8127 mL 7.6254 mL 19.0636 mL
15 mM 0.5084 mL 2.5418 mL 5.0836 mL 12.7091 mL
20 mM 0.3813 mL 1.9064 mL 3.8127 mL 9.5318 mL
25 mM 0.3050 mL 1.5251 mL 3.0502 mL 7.6254 mL
30 mM 0.2542 mL 1.2709 mL 2.5418 mL 6.3545 mL
40 mM 0.1906 mL 0.9532 mL 1.9064 mL 4.7659 mL
50 mM 0.1525 mL 0.7625 mL 1.5251 mL 3.8127 mL
60 mM 0.1271 mL 0.6355 mL 1.2709 mL 3.1773 mL
80 mM 0.0953 mL 0.4766 mL 0.9532 mL 2.3829 mL
100 mM 0.0763 mL 0.3813 mL 0.7625 mL 1.9064 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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