2. Apoptosis
  3. Apoptosis
  4. (S)-Oxiracetam

(S)-Oxiracetam  (Synonyms: (S)-奥拉西坦; (S)-(-)-Oxiracetam; (S)-ISF2522)

目录号: HY-126049 纯度: 98.78%
COA 产品使用指南

摩尔计算器

(S)-oxiracetam (S-ORC) 是一种靶向凋亡 (apoptosis) 的抑制剂。(S)-oxiracetam 在中脑动脉栓塞/再灌注模型 (middle cerebral artery occlusion/reperfusion, MCAO/R) 中可减少脑梗塞面积，减轻中风后的神经功能障碍。缺血性中风后，(S)-oxiracetam 通过 α7 nAChR 激活 PI3K/Akt/GSK3β 信号通路阻止神经元凋亡。S-ORC可预防缺血性中风后神经元死亡。

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(S)-Oxiracetam Chemical Structure

(S)-Oxiracetam Chemical Structure

CAS No. : 88929-35-5

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Other Forms of (S)-Oxiracetam:

(S)-Oxiracetam 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(S)-oxiracetam (S-ORC) is an inhibitor targeting apoptosis. S-ORC reduces brain infarct size and lessens neurological dysfunction in middle cerebral artery occlusion/reperfusion (MCAO/R) models. S-ORC prevents neuronal apoptosis via activating PI3K/Akt/GSK3β signaling pathway via α7 nAChR after ischemic stroke. S-ORC can prevent neuronal death after ischemic stroke[1].

体外研究
(In Vitro)

(S)-Oxiracetam (1，10，100 μM；24 h) 保护胎鼠原代皮层神经元免受 OGD/R 损伤并激活 PI3K/Akt/GSK3β 信号通路依赖于 α7 nAChR[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-Oxiracetam 相关抗体:

Cell Viability Assay[1]

Cell Line: fetal rat primary cortical neurons
Concentration: 1, 10, 100 μM
Incubation Time: 24 h
Result: Increased the survival of cortical neurons (58.82%, 64.82% and 79.15%, respectively) compared with the OGD/R group.

Cell Cytotoxicity Assay[1]

Cell Line: fetal rat primary cortical neurons
Concentration: 1, 10, 100 μM
Incubation Time: 24 h
Result: Decreased the LDH activity to 567.59 U/L, 484.89 U/L and 428.15 U/L at 1 μM, 10 μM and 100 μM, respectively, compared with the OGD/R group (725.22 U/L).

Apoptosis Analysis[1]

Cell Line: fetal rat primary cortical neurons
Concentration: 1, 10, 100 μM
Incubation Time: 24 h
Result: Reduced the apoptotic rate in cortical neurons dependent on α7 nAChR (34.48%, 16.15% and 10.05%, respectively) compared with the OGD/R group.

Western Blot Analysis[1]

Cell Line: fetal rat primary cortical neurons
Concentration: 1, 10, 100 μM
Incubation Time: 24 h
Result: Increased the expression of α7 nAChR (46.95%, 58.67% and 72.97%, respectively for the 1 μM, 10 μM and 100 μM) and the phosphorylation of PI3K, Akt and GSK3β dependent on α7 nAChR compared with the OGD/R group.
体内研究
(In Vivo)

(S)-Oxiracetam (0.12，0.24，0.48 g/kg；静脉注射，每天一次持续 7 天) 在雄性 Sprague-Dawley 大鼠诱导的 MACO/R 模型中，显著减少梗死面积，减轻行为功能障碍，抑制神经元凋亡并激活 PI3K/Akt/GSK3β 信号通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: scopolamine-induced amnesia models in Swiss albino mice[1].
Dosage: 0.12, 0.24, 0.48 g/kg, once daily for 7 days
Administration: Intravenous injection (i.v.)
Result: Decreased the infarct size of rats to 26.04 ± 1.07%, 21.66 ± 2.27%, 12.26 ± 5.59% compared with the sham group at 0.12 g/kg, 0.24 g/kg, 0.48 g/kg, respectively.
Increased neurological scores compared with the MCAO/R group.
Protected neurons from apoptosis compared to sham group.
Increased the α7 nAChR and the phosphorylation of PI3K, Akt and GSK3β expression compared with MCAO/R group.
Increased of GSH-PX concentration (189.54 units, 193.07 units, and 203.98 untis, respectively).
分子量

158.16

Formula

C6H10N2O3
CAS 号
性状

固体

颜色

White to off-white

中文名称

(S)-奥拉西坦
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 250 mg/mL (1580.68 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.3227 mL 31.6136 mL 63.2271 mL
5 mM 1.2645 mL 6.3227 mL 12.6454 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

(S)-Oxiracetam 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.3227 mL 31.6136 mL 63.2271 mL 158.0678 mL
5 mM 1.2645 mL 6.3227 mL 12.6454 mL 31.6136 mL
10 mM 0.6323 mL 3.1614 mL 6.3227 mL 15.8068 mL
15 mM 0.4215 mL 2.1076 mL 4.2151 mL 10.5379 mL
20 mM 0.3161 mL 1.5807 mL 3.1614 mL 7.9034 mL
25 mM 0.2529 mL 1.2645 mL 2.5291 mL 6.3227 mL
30 mM 0.2108 mL 1.0538 mL 2.1076 mL 5.2689 mL
40 mM 0.1581 mL 0.7903 mL 1.5807 mL 3.9517 mL
50 mM 0.1265 mL 0.6323 mL 1.2645 mL 3.1614 mL
60 mM 0.1054 mL 0.5269 mL 1.0538 mL 2.6345 mL
80 mM 0.0790 mL 0.3952 mL 0.7903 mL 1.9758 mL
100 mM 0.0632 mL 0.3161 mL 0.6323 mL 1.5807 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Oxiracetam88929-35-5(S)-(-)-Oxiracetam (S)-ISF2522(S)-奥拉西坦Apoptosiscortical neuronsmiddle cerebral artery occlusion/reperfusion (MCAO/R) model in ratsbrain injury from ischemic strokeInhibitorinhibitorinhibit

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