1. Cell Cycle/DNA Damage
  2. DNA Alkylator/Crosslinker
  3. Satraplatin

Satraplatin  (Synonyms: 沙铂; BMS182751; BMY45594; JM216)

目录号: HY-17576 纯度: 99.82%
COA 产品使用指南

Satraplatin 是一种烷化剂 (alkylator),具有抗肿瘤效果。

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Satraplatin Chemical Structure

Satraplatin Chemical Structure

CAS No. : 129580-63-8

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
1 mg ¥1150
In-stock
5 mg ¥2800
In-stock
10 mg ¥4000
In-stock
50 mg ¥8700
In-stock
100 mg   询价  
200 mg   询价  

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Top Publications Citing Use of Products
  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Satraplatin is an alkylating agent, with potent antitumor effect.

体外研究
(In Vitro)

Satraplatin needs to avoid light in the solution, and it is unstable in the alkaline state but stable in the acidic state.
Satraplatin has potent antitumor activity. Satraplatin combined with dichloroacetate (DCA) inhibits UMC-11 cells with an IC50 of 1.36 ± 0.11 μM[1]. Satraplatin also suppresses CDDP-resistant (KB-R) cells (IC50, 7.04 μM), and causes G2/M arrest in KB-R cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

500.28

Formula

C10H22Cl2N2O4Pt

CAS 号
性状

固体

颜色

Off-white to yellow

中文名称

赛特铂;沙铂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMF 中的溶解度 : 10 mg/mL (19.99 mM; 超声助溶; 酸性条件溶解 (HCL 调节,pH≈1); DMSO can inactivate Satraplatin's activity)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble; DMSO can inactivate Satraplatin's activity)

Ethanol 中的溶解度 : < 1 mg/mL (insoluble; DMSO can inactivate Satraplatin's activity)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9989 mL 9.9944 mL 19.9888 mL
5 mM 0.3998 mL 1.9989 mL 3.9978 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.82%

参考文献
Cell Assay
[1]

Cells are harvested, counted and distributed to microtiter plates in 100 μL medium at a density of 1×104 cells/well. Appropriate dilutions of test compounds (Satraplatin, etc.) are added to a total volume of 200 μL/well and plates incubated under tissue culture conditions for four days. Stock solutions of the compounds are prepared in either 70% ethanol or DMSO and diluted more than 100-fold for the assays. Solvent controls are included in all tests. Dose response curves are obtained by assessing cell proliferation at twofold drug dilutions in triplicate and used for calculation of IC50 values. Cell growth is quantified using a modified tetrazolium dye assay (MTT) and by measurement of the reduced formazane dye at 450 nm wavelength (medium control set to 100% proliferation)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 1.9989 mL 9.9944 mL 19.9888 mL 49.9720 mL
5 mM 0.3998 mL 1.9989 mL 3.9978 mL 9.9944 mL
10 mM 0.1999 mL 0.9994 mL 1.9989 mL 4.9972 mL
15 mM 0.1333 mL 0.6663 mL 1.3326 mL 3.3315 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Satraplatin
目录号:
HY-17576
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