绞股蓝皂苷L
Gypenoside L 是一种皂苷,存在于 Gynostemma pentaphyllum 中。Gypenoside L 增加 SA-β-半乳糖苷酶活性,促进衰老相关分泌细胞因子的产生。Gypenoside L 还可以激活 p38 和 ERKMAPK 通路和 NF-κB 通路以诱导衰老。Gypenoside L 具有抗肿瘤和抗炎活性。
3-脱氧苏木酮 B
Deoxysappanone B (3-Deoxysappanone B) 是一种从 Caesalpinia sappan L (Lignum Sappan) 分离得到的异黄酮化合物。Deoxysappanone B 具有抗神经炎症和神经保护作用,可以通过阻断 IκB kinase (IKK)-NF-κB 和 p38/ERKMAPK 途径的信号通路,抑制神经炎症介质的产生。Deoxysappanone B 可用于神经炎和炎症相关的神经损伤的疾病研究。
Verrucarin A (Muconomycin A) 是一种 D 型大环真菌毒素,来源于Myrothecium verrucaria,是一种蛋白质合成 (protein synthesis) 的抑制剂。Verrucarin A 抑制白血病细胞系生长,激活巨噬细胞 caspases、凋亡和炎症信号。Verrucarin A 能有效提高 p38 MAPK 的磷酸化,降低 ERK/Akt 的磷酸化。Verrucarin A 通过 p21 和 p53 的诱导引起细胞周期调控的解除。
Cudraflavone B 是一种异戊二烯化类黄酮,具有抗炎和抗癌特性。Cudraflavone B 也是 COX-1 和 COX-2 的双重抑制剂。Cudraflavone B 阻断巨噬细胞中 核因子 κB (NF-κB) 从细胞质到细胞核的易位。由此,Cudraflavone B 也抑制肿瘤坏死因子 α (TNFα) 的基因表达和分泌。Cudraflavone B 还触发线粒体凋亡通路,激活 NF-κB、MAPK p38 和 ERK,并诱导 SIRT1 的表达。由此,Cudraflavone B 抑制人口腔鳞状细胞癌细胞的生长。
绞股蓝皂苷L
Gypenoside L 是一种皂苷,存在于 Gynostemma pentaphyllum 中。Gypenoside L 增加 SA-β-半乳糖苷酶活性,促进衰老相关分泌细胞因子的产生。Gypenoside L 还可以激活 p38 和 ERKMAPK 通路和 NF-κB 通路以诱导衰老。Gypenoside L 具有抗肿瘤和抗炎活性。
3-脱氧苏木酮 B
Deoxysappanone B (3-Deoxysappanone B) 是一种从 Caesalpinia sappan L (Lignum Sappan) 分离得到的异黄酮化合物。Deoxysappanone B 具有抗神经炎症和神经保护作用,可以通过阻断 IκB kinase (IKK)-NF-κB 和 p38/ERKMAPK 途径的信号通路,抑制神经炎症介质的产生。Deoxysappanone B 可用于神经炎和炎症相关的神经损伤的疾病研究。
Cudraflavone B 是一种异戊二烯化类黄酮,具有抗炎和抗癌特性。Cudraflavone B 也是 COX-1 和 COX-2 的双重抑制剂。Cudraflavone B 阻断巨噬细胞中 核因子 κB (NF-κB) 从细胞质到细胞核的易位。由此,Cudraflavone B 也抑制肿瘤坏死因子 α (TNFα) 的基因表达和分泌。Cudraflavone B 还触发线粒体凋亡通路,激活 NF-κB、MAPK p38 和 ERK,并诱导 SIRT1 的表达。由此,Cudraflavone B 抑制人口腔鳞状细胞癌细胞的生长。
Phospho-MEK1 (Ser298) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 43 kDa, targeting to Phospho-MEK1 (Ser298). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.
Phospho-MEK1 (Thr292) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 43 kDa, targeting to Phospho-MEK1 (Thr292). It can be used for WB assays with tag free, in the background of Mouse, Rat.
Phospho-MEK4 (Ser80) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 44 kDa, targeting to Phospho-MEK4 (Ser80). It can be used for WB,IP assays with tag free, in the background of Human.
ASK1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 155 kDa, targeting to ASK1. It can be used for WB,IHC-P,ICC/IF,FC assays with tag free, in the background of Human, Mouse.
Phospho-ASK1 (Ser966) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 155 kDa, targeting to Phospho-ASK1 (Ser966). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.
Phospho-ERK1/2 (Thr202/Thr185) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 44,42 kDa, targeting to Phospho-ERK1/2 (Thr202/Thr185). It can be used for WB,IP assays with tag free, in the background of Human, Hamster, Rat.
Phospho-ERK1/2 (Tyr204/Tyr187) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 42,44 kDa, targeting to Phospho-ERK1/2 (Tyr204/Tyr187). It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.
Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 44,42 kDa, targeting to Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.
ERK1 + ERK2 (phospho Thr183/Tyr185); phospho-ERK1/MAPK-1/2(Thr183/Tyr185); ERK 1; ERK 2; ERK-2; ERK1; ERK2; ERT1; ERT2; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 2; Extracellular signal regulated kinase 2; Extracellular signal-regulated kinase 2; HS44KDAP; HUMKER1A; Insulin stimulated MAP2 kinase; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAP kinase isoform p44; MAPK 1; MAPK 2; MAPK1; MAPK2; MGC20180; Microtubule associated protein 2 kinase; Mitogen activated protein kinase 1; Mitogen activated protein kinase 1; Mitogen activated protein kinase 2; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; MK01_MOUSE; p38; p40; p41; p41MAPK; p42 MAPK; p42-MAPK; p42MAPK; p42MAPK; p44 ERK1; p44 MAPK; p44ERK1; p44ERK1; p44MAPK; p44MAPK; PRKM 1; PRKM 1; PRKM 2; PRKM 2; PRKM1; PRKM2; Protein kinase mitogen activated 1; Protein kinase mitogen activated 1; Protein kinase mitogen activated 2; Protein kinase mitogen activated 2; Protein tyrosine kinas.
WB; ELISA; IHC-P; IHC-F; ICC; IF
Human, Mouse(predicted: Rat, Chicken, Dog, Cow, Horse, Rabbit, Guinea Pig)
phospho-ERK1 + 2 (Thr183/Tyr185) Antibody is an unconjugated, approximately 42/44 kDa, rabbit-derived, anti-phospho-ERK1 + 2 (Thr183/Tyr185) polyclonal antibody. phospho-ERK1 + 2 (Thr183/Tyr185) Antibody can be used for: WB, ELISA, IHC-P, IHC-F, ICC, IF expriments in human, mouse, and predicted: rat, chicken, dog, cow, horse, rabbit, guinea pig background without labeling.
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