2. MAPK/ERK Pathway
  3. Raf
  4. SHR902275

SHR902275 是一种有效、选择性和口服活性 RAF 抑制剂，靶向 RAS 突变癌症。 对于 cRAF、bRAFwt 和 bRAFV600E，SHR902275 对 cRAF, bRAFwt, bRAFV600E 的 IC50 分别为 1.6 nM、10 nM、5.7 nM。 SHR902275 显示细胞生长抑制作用，对 H358、A375、Calu6 和 SK-MEL2 细胞的 GI50 分别为 1.5 和 0.17 nM、0.4 nM 和 0.32 nM .

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SHR902275 Chemical Structure

SHR902275 Chemical Structure

CAS No. : 2695506-82-0

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SHR902275 相关抗体

Top Publications Citing Use of Products

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BRaf c-Raf Raf

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SHR902275 is a potent, selective, and orally active RAF inhibitor targeting RAS mutant cancers. SHR902275 has IC50s of 1.6 nM, 10 nM, and 5.7 nM for cRAF, bRAFwt, and bRAFV600E, respectively. SHR902275 shows cell growth inhibition with GI50s of 1.5 and 0.17 nM, 0.4 nM and 0.32 nM for H358, A375, Calu6, and SK-MEL2 cells respectively[1].

IC50 & Target[1]

c-Raf

1.6 nM (IC50)

BRafV600E

5.7 nM (IC50)

BRAFWT

10 nM (IC50)

分子量

512.48

Formula

C26H23F3N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SHR902275 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHR9022752695506-82-0SHR 902275SHR-902275RafRaf kinasescRAFbRAF wtbRAF V600EmutationH358A375SK-MEL2Calu6 cellsInhibitorinhibitorinhibit

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产品名称：
SHR902275
目录号：
HY-144269
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