Simvastatin acid-d₉ ammonium  (Synonyms: 辛伐他汀铵盐-d₉; Tenivastatin-d₉ ammonium)

Simvastatin acid-d₉ ammonium is deuterated labeled Simvastatin acid ammonium (HY-119695A). Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene^[1][2].

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。
Simvastatin acid (0.1 -20 μM；24 h) 在硫酸吲哚酚处理的 hCM 细胞中，ROS 产量显著降低 8.9% 至 43%^[3]。
Simvastatin acid (0.1 -20 μM；24 h) 改变了 hCM-表达 和 OATP3A1-表达 的 HEK293 细胞中 OATP3A1 的蛋白表达^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

448.64

C₂₄H₃₂D₉NO₆

139893-43-9

辛伐他汀羟酸铵盐-d₉

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Eduardo Filipe Oliveira, et al. HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015). Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272.  [Content Brief]

  [3]. Atilano-Roque A, et al. Characterization of simvastatin acid uptake by organic anion transporting polypeptide 3A1 (OATP3A1) and influence of drug-drug interaction. Toxicol In Vitro. 2017 Dec;45(Pt 1):158-165.  [Content Brief]