2. Stem Cell/Wnt
  3. Smo
  4. SMO-IN-4

SMO-IN-4 (Compound 24) 是一种有效的具有口服活性的 smoothened 拮抗剂 (IC50: 24 nM)。SMO-IN-4 具有抗肿瘤活性。

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SMO-IN-4 Chemical Structure

SMO-IN-4 Chemical Structure

CAS No. : 1567963-99-8

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SMO-IN-4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SMO-IN-4 (Compound 24) is a potent and orally active smoothened antagonist (IC50: 24 nM). SMO-IN-4 has antitumor activity[1].

体外研究
(In Vitro)

SMO-IN-4 (10 µM) 对所有 CYP 亚型的抑制作用极小，对 hERG 的抑制也较低 (IC50 = 38 µM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SMO-IN-4 相关抗体:
体内研究
(In Vivo)

在 Ptch1+/- 小鼠髓母细胞瘤皮下异种移植模型中，SMO-IN-4 (50 mg/kg，每日口服灌胃) 可导致皮下肿瘤消退[2]。
SMO-IN-4 (Compound 24)的药代特性[2]。

Species Dose (mg/kg) AUC0-24h (ng·h/mL) Cmax (ng/mL) t1/2 (h) F%
Mouse p.o. (10 mg/kg) 4183 4132 1.0 49
Rat p.o. (10 mg/kg) 5541 2180 2.3 62
Dog p.o. (5 mg/kg) 7656 1300 5.4 72

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

450.96

Formula

C24H27ClN6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SMO-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMO-IN-41567963-99-8SmoSmoothenedtumorxenograft modelPtch1medulloblastomaInhibitorinhibitorinhibit

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目录号：
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