2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Sofituzumab vedotin

Sofituzumab vedotin  (Synonyms: DMUC5754A)

目录号: HY-P99593 纯度: 98.72%
COA

摩尔计算器

Sofituzumab vedotin (DMUC5754A) 是一种含有 MMAE 的抗 MUC16 抗体-药物偶联物 (ADC)，具有蛋白酶切割连接子。Sofituzumab vedotin 可用于癌症研究。

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Sofituzumab vedotin Chemical Structure

Sofituzumab vedotin Chemical Structure

CAS No. : 1418200-58-4

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Sofituzumab vedotin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sofituzumab vedotin (DMUC5754A) is a MMAE-containing anti-MUC16 antibody-drug conjugate (ADC) with a protease-cleavable linker. Sofituzumab vedotin can be used for the research of cancer[1].

体外研究
(In Vitro)

Sofituzumab vedotin (DMUC5754A) 是一种抗体-药物偶联物 (ADC)，包含人源化 IgG1 抗 MUC16 单克隆抗体和一种有效的抗有丝分裂剂 MMAE，通过蛋白酶不稳定的连接子 maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl 连接[2]。
Sofituzumab vedotin (3A5-VC-MMAE; 0.1-10000ng/mL; 3 or 5 days) 以剂量依赖方式抑制 OVCAR-3 和 PC3/MUC16TMlong 细胞增殖[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sofituzumab vedotin 相关抗体:

Cell Proliferation Assay[3]

Cell Line: OVCAR-3 and PC3/MUC16TMlong cells
Concentration: 0.1-10000 ng/mL
Incubation Time: 3 days for OVCAR-3 and 5 days for PC3/MUC16TMlong
Result: Significantly inhibited cell proliferation above 100 ng/mL.
体内研究
(In Vivo)

Sofituzumab vedotin (3A5-VC-MMAE; 2 and 2.8 mg/kg; IV; once weekly for 3 or 4 total doses) 在 MUC16 表达的人 OVCAR-3 小鼠异种移植物模型中显示出强大的抗肿瘤活性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CB17 ICR severe combined immunodeficient mice, OVCAR-3/luc mouse xenografts[3]
Dosage: 2.8 mg/kg
Administration: IV, once weekly for 4 total doses
Result: Improved survival.
Animal Model: Female CB17 ICR severe combined immunodeficient mice, OVCAR-3 tumors grown in the mammary fat pads[3]
Dosage: 2 mg/kg
Administration: IV, once weekly for 3 total doses
Result: Significantly decreased the tumor volume.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

维汀-索非妥珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sofituzumab vedotin 相关分类

  • 摩尔计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sofituzumab vedotin1418200-58-4DMUC5754A维汀-索非妥珠单抗Antibody-Drug Conjugates (ADCs)Antibody-Drug Conjugatesovarian cancerpancreatic cancerOVCAR-3PC3/MUC16TMlongInhibitorinhibitorinhibit

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