2. TGF-beta/Smad
  3. TGF-β Receptor
  4. Stamulumab

Stamulumab  (Synonyms: MYO-029)

目录号: HY-P99588

摩尔计算器

Stamulumab (MYO-029) 是一种重组人 IgG1λ 抗体，可与肌肉生长抑制素 (myostatin) 结合并通过阻止与其内源性高亲和力受体 ActRIIB 的结合来中和其活性。Stamulumab 导致 SCID 小鼠的肌纤维肥大而不是增生。Stamulumab 具有用于贝克尔肌营养不良症 (BMD)、面肩肱型营养不良症 (FSHD) 和肢带型肌营养不良症 (LGMD) 研究的潜力。

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Stamulumab Chemical Structure

Stamulumab Chemical Structure

CAS No. : 705287-60-1

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规格 价格 是否有货
1 mg ￥2400
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5 mg ￥6200
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10 mg ￥9900
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Stamulumab 相关抗体

Top Publications Citing Use of Products

查看 TGF-β Receptor 亚型特异性产品:

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ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research[1][2].

同型

Human IgG1 lambda1
推荐同型对照抗体
种属

Human
体内研究
(In Vivo)

Stamulumab (MYO-029; 腹腔给药; 1-10 mg/kg/周; 持续 12 周) 在 SCID 小鼠体内以浓度依赖性方式增加骨骼肌质量。Stamulumab 导致肌纤维肥大而不是增生[1]。
Stamulumab (静脉注射; 1, 5, 20, 100 mg/kg/周; 持续 4 周) 在 C57/SCID 小鼠中的中心清除率 (CL) 为 0.25 mL/h/kg[1].
Pharmacokinetic Parameters of Stamulumab (MYO-029)[1].

C57/SCID mice IV (1-100 mg/kg/week for 4 weeks) Sprague Dawley rats (2-50 mg/kg; single injection) Cynomolgus monkeys (10-100 mg/kg/week for 5 or 39 weeks)
CL (mL/h/kg) 0.245 0.542 0.228
Volume of central compartment (mL/kg) 103 58.9 41.8
Distributive clearance (mL/h/kg) 1.79 0.815

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female SCID mice[1]
Dosage: 1, 2.5, 5, 10 mg/kg
Administration: IP; every week for 12 weeks
Result: Increased skeletal muscle mass in vivo in a concentration‐dependent manner.
Clinical Trial
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Stamulumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Stamulumab705287-60-1MYO-029MYO029MYO 029TGF-β ReceptorTransforming growth factor beta receptorsIgG1λmyostatinActRIIBmuscle fiber hypertrophyBecker muscular dystrophyBMDfacioscapulohumeral dystrophyFSHDlimb-girdle muscular dystrophyLGMDInhibitorinhibitorinhibit

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