2. Immunology/Inflammation
  3. STING
  4. STING-IN-5

STING-IN-5 是一种有效的 STING 抑制剂，在巨噬细胞中抑制 LSP 诱导的 NO 合成，IC50 为 1.15 μM。STING-IN-5 抑制炎症反应。STING-IN-5 可用于研究抗炎疾病和败血症。

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STING-IN-5 Chemical Structure

STING-IN-5 Chemical Structure

CAS No. : 2920064-17-9

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规格 价格 是否有货 数量
1 mg ￥2900
In-stock
5 mg ￥6400
In-stock
10 mg   询价  
50 mg   询价  

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STING-IN-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STING-IN-5 is a potent STING inhibitor, inhibiting LPS-induced NO synthesis in macrophages with an IC50 value of 1.15 μM. STING-IN-5 inhibits the inflammatory response. STING-IN-5 can be used to research anti-inflammatory diseases and sepsis[1].

体外研究
(In Vitro)

STING-IN-5 (化合物30) (40 μM; 24 h) 对 RAW264.7 细胞活力影响较小[1]。
STING-IN-5 (2.5 和 5 μM; 2 h) 抑制 LPS 刺激的 RAW264.7 细胞产生 NO，在 2.5 μM 和 5 μM 下的抑制率分别为 69.28 ± 2.36% 和 78.66 ± 2.73%，IC50 为 1.15 ± 0.15 μM[1]。
STING-IN-5 (0.5-2 μM; 2 h) 抑制 STING，以及 TBK1/IRF3/NF-κB 激活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STING-IN-5 相关抗体:

Cell Viability Assay[1]

Cell Line: RAW264.7
Concentration: 40 μM
Incubation Time: 24 h
Result: Exhibited less effect on RAW264.7 cell viability of 91.08 ± 1.09%

Western Blot Analysis[1]

Cell Line: RAW264.7 (stimulated by LPS for 6 h)
Concentration: 0.5, 1 and 2 μM
Incubation Time: 2 h
Result: Significantly inhibited the protein expression of STING and the phosphorylation of the downstream targets TBK1, IRF3, p65, and IκB in a concentration-dependent manner.
体内研究
(In Vivo)

STING-IN-5 (1.25-5 mg/kg；灌胃；每日 1 次，连续 3 天) 对脓毒症小鼠急性肝损伤有明显保护作用[1]。
Pharmacokinetic Parameters of STING-IN-5 in male Sprague-Dawley rats[1].

Tmax (h) Cmax (ng/mL) AUC0-t (ng/mL·h) AUC0-∞ (ng/mL·h) T1/2 (h) MRT0-t (h) MRT0-∞ (h)
1 66.52 81.08 135.7 1.11 0.99 2.02

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice (6-8 weeks; acute liver injury induced by injection of 10 mg/kg LPS)[1]
Dosage: 1.25, 2.5, 5 mg/kg
Administration: i.g.; once daily; for 3 days
Result: Significantly improved pathological changes including disorderly arranged liver cells, blurred boundaries, congested hepatic sinusoids, swollen hepatocytes, a small number of hepatocytes were necrotic, and inflammatory cells infiltrated local areas.
Significantly reduced the levels of AST, ALT, and ALP (liver function specific indicators).
分子量

854.17

Formula

C47H67NO9S2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (117.07 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1707 mL 5.8536 mL 11.7073 mL
5 mM 0.2341 mL 1.1707 mL 2.3415 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

STING-IN-5 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1707 mL 5.8536 mL 11.7073 mL 29.2682 mL
5 mM 0.2341 mL 1.1707 mL 2.3415 mL 5.8536 mL
10 mM 0.1171 mL 0.5854 mL 1.1707 mL 2.9268 mL
15 mM 0.0780 mL 0.3902 mL 0.7805 mL 1.9512 mL
20 mM 0.0585 mL 0.2927 mL 0.5854 mL 1.4634 mL
25 mM 0.0468 mL 0.2341 mL 0.4683 mL 1.1707 mL
30 mM 0.0390 mL 0.1951 mL 0.3902 mL 0.9756 mL
40 mM 0.0293 mL 0.1463 mL 0.2927 mL 0.7317 mL
50 mM 0.0234 mL 0.1171 mL 0.2341 mL 0.5854 mL
60 mM 0.0195 mL 0.0976 mL 0.1951 mL 0.4878 mL
80 mM 0.0146 mL 0.0732 mL 0.1463 mL 0.3659 mL
100 mM 0.0117 mL 0.0585 mL 0.1171 mL 0.2927 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STING-IN-52920064-17-9STINGStimulator of Interferon GenesTMEM173MITAERISMPYSanti-inflammatorysepsisRAW264.7liver injuryInhibitorinhibitorinhibit

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