2. NF-κB Immunology/Inflammation
  3. NF-κB PD-1/PD-L1
  4. Sulindac sodium

Sulindac sodium  (Synonyms: 舒林酸(钠); MK-231 sodium)

目录号: HY-B0008A
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摩尔计算器

Sulindac (MK-231) 是一种口服活性非甾体类抗炎药。 Sulindac 也是一种免疫调节剂。 Sulindac 可用于脊柱关节炎、痛风性关节炎及多种癌症如结直肠癌、肺癌的研究。

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Sulindac sodium Chemical Structure

Sulindac sodium Chemical Structure

CAS No. : 63804-15-9

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Sulindac sodium 的其他形式现货产品:

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Sulindac sodium 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sulindac (MK-231) is an orally active nonsteroidal anti-inflammatory agent. Sulindac also is an immunomodulatory agent. Sulindac can be used for the research of arthritis of the spine, gouty arthritis and kinds of cancer including colorectal cancer (CRC) and lung cancer[1][2].

体外研究
(In Vitro)

Sulindac (MK-231) (500 μM, 48 h) sodium is effective in preventing TGF-β1-induced EMT, as indicated by upregulation of the epithelial marker, E-cadherin, and downregulation of mesenchymal markers and transcription factors[1].
Sulindac sodium (500 μM, 48 h) can inhibit TGF-β1-enhanced migration and invasion of A549 cells[1].
Sulindac sodium (500 μM, 48 h) enhances the reversal of TGF-β1-induced EMT by sulindac (sodium) and SIRT1 upregulation promoted TGF-β1-induced EMT[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sulindac sodium 相关抗体:

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 500 μM
Incubation Time: 48 h
Result: Inhibit transforming growth factor (TGF)-β1-induced epithelial-mesenchymal transition in A549 cells.

Immunofluorescence[1]

Cell Line: A549 cells
Concentration: 500 μM
Incubation Time: 48 h
Result: Reversed SIRT-1 expression by TGF-β1 and inhibited the TGF-β1-induced cadherin switch.

Cell Migration Assay [1]

Cell Line: A549 cells
Concentration: 500 μM
Incubation Time: 48 h
Result: Inhibited migration, decreased resistance co-treatment with TGF-β1.

Cell Invasion Assay[1]

Cell Line: A549 cells
Concentration: 500 μM
Incubation Time: 40 h; 48 h
Result: Could effectively inhibit the TGF- β1-induced increase in invasion by lung cancer cells.
体内研究
(In Vivo)

Sulindac (MK-231) sodium (15 mg/kg, p.o., bid (sulindac alone); 7.5 mg/kg p.o., bid (sulindac combination with PD-L1)) shows a significant reduction in tumor volume and increases infiltration of CD8+ T lymphocytes in the tumor tissues when treated with combination therapy[2].
Sulindac sodium (15 mg/kg, p.o., bid (sulindac alone); 7.5 mg/kg p.o., bid (sulindac combination with PD-L1)) can downregulate PD-L1 by blocking NF-κB signaling, which in turn led to a decrease in exosomal P[2].
Sulindac sodium (15 mg/kg, p.o., bid (sulindac alone); 7.5 mg/kg p.o., bid (sulindac combination with PD-L1)) leads to increased availability of PD-L1 Ab by downregulating PD-L1 in combination therapy[2].
Sulindac sodium has not a systemic inhibitory effect on prostaglandin E2 (PGE2) in low-dose does[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT26 syngeneic mouse tumor model[2]
Dosage: 15 mg/kg; 7.5 mg/kg
Administration: 15 mg/kg, p.o., bid (sulindac alone); 7.5 mg/kg p.o., bid (sulindac combination with PD-L1)
Result: Downregulated PD-L1 through the blockade of NF-κB signaling and modulate the response of pMMR CRC to anti-PD-L1 immunotherapy.
Animal Model: CT26 syngeneic mouse tumor model[2]
Dosage: 15 mg/kg; 7.5 mg/kg
Administration: 15 mg/kg, p.o., bid (sulindac alone); 7.5 mg/kg p.o., bid (sulindac combination with PD-L1)
Result: Downregulated PD-L1 through the blockade of NF-κB signaling and modulate the response of pMMR CRC to anti-PD-L1 immunotherapy.
Cound effectively inhibit PD-L1 with no significant systematic toxicity.
Clinical Trial
分子量

378.39

Formula

C20H16FNaO3S
CAS 号
中文名称

舒林酸(钠)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sulindac sodium 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulindac63804-15-9MK-231舒林酸(钠)MK231MK 231NF-κBPD-1/PD-L1Nuclear factor-κBNuclear factor-kappaBPD-1/Programmed death-ligand 1oralnonsteroidalanti-inflammatoryimmunomodulatory agentFDANSAIDcolorectal cancer (CRC)pMMRTGF-β1epithelial-mesenchymal transition (EMT)SIRT1lung cancermigrationinvasionInhibitorinhibitorinhibit

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