Tachysterol 3  (Synonyms: 速甾醇3)

Tachysterol 3 is a photoproduct of Previtamin D₃ (HY-130705)^[1][2].

Tachysterol 3 can be hydroxylated by CYP11A1 and CYP27A1^[2].
Tachysterol 3 is detected in human serum at a concentration of 7.3 ± 2.5 ng/mL^[2].
Tachysterol 3 hydroxyderivatives show high-affinity binding to the ligan-binding domain (LBD) of the liver X receptor (LXR) α and β, and the peroxisome proliferator-activated receptor γ (PPARγ) in LanthaScreen TR-FRET coactivator assays^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

384.64

C₂₇H₄₄O

17592-07-3

油状物

Colorless to light yellow

胆钙化醇EP杂质E (Tachysterol 3)

Shipping with dry ice.

-80°C, protect from light, stored under nitrogen

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• [1]. Cecilia Cisneros, et al. The Role of Tachysterol in Vitamin D Photosynthesis - A Non-Adiabatic Molecular Dynamics Study. Phys Chem Chem Phys. 2017 Feb 22;19(8):5763-5777.  [Content Brief]

  [2]. Slominski AT, et al. Metabolic activation of tachysterol3 to biologically active hydroxyderivatives that act on VDR, AhR, LXRs, and PPARγ receptors. FASEB J. 2022 Aug;36(8):e22451.  [Content Brief]