2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Antifolate Dihydrofolate reductase (DHFR)
  4. Talotrexin

Talotrexin (PT523) 是一种 Aminopterin (HY-14518) 的类似物，是一种非聚谷氨酸化的经典抗叶酸剂 (antifolate)。 Talotrexin 是一种 RFC (还原型叶酸载体)的特异性抑制剂，可选择性地抑制 RFC 转运。Talotrexin 通过靶向 DHFR 抑制肿瘤生长显示出抗肿瘤活性。

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Talotrexin Chemical Structure

Talotrexin Chemical Structure

CAS No. : 113857-87-7

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Talotrexin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Talotrexin (PT523), an analog of Aminopterin (HY-14518), is a nonpolyglutamatable classic antifolate. Talotrexin is a RFC (reduced folate carrier) specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitumor activity by targeting DHFR to inhibit tumor growth[1][2].

体外研究
(In Vitro)

Talotrexin 未显示出显著的 PCFT 或 FRα 抑制活性[1]。
Talotrexin (1-1000 nM) 可抑制 R1-11/Tet-on-RFC HeLa 细胞的增殖[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Talotrexin 相关抗体:
体内研究
(In Vivo)

Talotrexin (0-35 mg/kg，静脉注射，每周一次，持续 4 周) 单独或与Paclitaxel (HY-B0015, 7.5 mg/kg) 联合使用可抑制小鼠 A549 肿瘤的生长[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSCLC xenografts in athymic female nude mice (6-8 weeks)[2]
Dosage: 15, 25, and 35 mg/kg, combined with Paclitaxel (HY-B0015, 7.5 mg/kg)
Administration: IV injection, once weekly for 4 weeks
Result: Inhibited A549 tumor growth.
Clinical Trial
分子量

573.56

Formula

C27H27N9O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Talotrexin 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Talotrexin113857-87-7PT523PT 523PT-523AntifolateDihydrofolate reductase (DHFR)R1-11Tet-on-RFCHeLa cellsDHFRreduced folate carrierantifolateNSCLCA549 tumorInhibitorinhibitorinhibit

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