2. Inhibitory Antibodies
  3. Telitacicept

Telitacicept  (Synonyms: RC18)

目录号: HY-P99568 纯度: 99.30%
COA

摩尔计算器

Telitacicept (RC18) 是一种完全人 TACI-Fc 融合蛋白。Telitacicept 是一种双重 B 淋巴细胞刺激剂 (BLyS)/APRIL (一种增殖诱导配体) 抑制剂，可有效阻断 B 淋巴细胞的增殖。Telitacicept 可用于 B 细胞自身免疫性疾病的研究。

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Telitacicept Chemical Structure

Telitacicept Chemical Structure

CAS No. : 2136630-26-5

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规格 价格 是否有货 数量
1 mg ￥1250
In-stock
5 mg ￥3250
In-stock
10 mg ￥5200
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Telitacicept 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Telitacicept (RC18) is a fully human TACI-Fc fusion protein. Telitacicept is a dual B lymphocyte stimulator (BLyS)/APRIL (a proliferation-inducing ligand) inhibitor that effectively blocks proliferation of B lymphocytes. Telitacicept can be used in research of B-cell autoimmune disease[1].

IC50 & Target

(BLyS)/APRIL[1]
体内研究
(In Vivo)

Telitacicept (15 和 7.5mpk，腹腔注射) 可改善 MOG35-55 诱导的 EAE 模型小鼠的实验性自身免疫性脑脊髓炎 (EAE) 临床症状[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MOG35-55 peptide-induced EAE mice model (6- to 8-week-old, female)[2]
Dosage: 15mpk and 7.5mpk
Administration: i.p.
Result: Reduced the severity of tail paralyses and limb weakness in mice, but not as high efficacy as equal dose of Secukinumab (HY-P9927).
Decreased the number of infiltrating inflammatory cells around the white matter in spinal cord.
Clinical Trial
CAS 号
性状

固体

颜色

White to off-white

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.30%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Telitacicept2136630-26-5RC18RC 18RC-18Othersfusion proteinB lymphocyte proliferationautoimmuneInhibitorinhibitorinhibit

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