2. Anti-infection
  3. Bacterial Antibiotic
  4. Temafloxacin

Temafloxacin  (Synonyms: TMFX; TA-167 free acid; A-62254 free acid)

目录号: HY-16487 纯度: 99.65%
COA 产品使用指南

摩尔计算器

Temafloxacin (TMFX) 是一种口服有效的喹诺酮类广谱抗菌剂。Temafloxacin 对下呼吸道和泌尿生殖道感染具有较好的耐受性。

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Temafloxacin Chemical Structure

Temafloxacin Chemical Structure

CAS No. : 108319-06-8

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5 mg ￥1000
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25 mg ￥2800
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Customer Review

Other Forms of Temafloxacin:

Temafloxacin 相关抗体

Top Publications Citing Use of Products

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Temafloxacin (TMFX) is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin is well tolerated in lower respiratory and genitourinary tract infections[1][2].

IC50 & Target

Quinolone

 

体外研究
(In Vitro)

Temafloxacin (0-64 µg/mL; 18-24 h) shows good antibacterial activity for gram-positive/negative bacteria, with MIC ranges of <0.004-0.5, 0.5-2 and 0.06-0.25 µg/mL for E. coli, P. aeruginosa, and S. aureus, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Temafloxacin 相关抗体:

Cell Viability Assay[1]

Cell Line: E. coli (16 strains), P. aeruginosa (13 strains), and S. aureus (17 strains).
Concentration: 0-64 µg/mL
Incubation Time: 18-24 h
Result: Inhibited E. coli (16 strains), P. aeruginosa, and S. aureus with MIC ranges of <0.004-0.5 (MIC 90%=0.06, =0.06), 0.5-2 (MIC 90%=1, MIC 50%=1) and 0.06-0.25 µg/mL (MIC 90%=0.125, MIC 50%=0.125). MIC 90% and 50% means MIC for 90% and 50% of the isolates (unit: µg/mL).
体内研究
(In Vivo)

Temafloxacin (6.25, 25, 100 mg/kg; p.o.; single) shows good inhibitory activity to murine pyelonephritis[1].
Temafloxacin hydrochloride (100 mg/kg; p.o. or s.c.; single) shows rapid gastrointestinal absorption, and has excellent tissue and body fluid penetration and concentration (except for central nervous system (CNS))[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CF-1 mice (20-25 g) (murine pyelonephritis model)[1].
Dosage: 6.25, 25, 100 mg/kg
Administration: Orally; single.
Result: Reduced the number of viable bacteria in the kidneys of mice.
Animal Model: Female CF-1 mice (20-25 g)[1].
Dosage: 100 mg/kg
Administration: Subcutaneously or orally; single.
Result: 1.19 Pharmacokinetic Parameters of Temafloxacin hydrochloride in Female CF-1 mice[1].
Cmax (µg/mL) AUC (µg/mL•h) T1/2 (h) % Urinary recovery
SC (100 mg/kg) 25.2 86.6 3.4 25.3
PO (100 mg/kg) 13.5 57.4 1.3 9.1
分子量

417.38

Formula

C21H18F3N3O3
CAS 号
性状

固体

颜色

White to off-white

中文名称

替马沙星
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂： 10% DMSO    90% Corn Oil

    Solubility: ≥ 0.5 mg/mL (1.20 mM); 澄清溶液

    此方案可获得 ≥ 0.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。

    以 1 mL 工作液为例，取 100 μL 5.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Temafloxacin 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Temafloxacin108319-06-8TMFXTA-167A-62254替马沙星TA167TA 167A62254A 62254BacterialAntibioticE. coliP. aeruginosaS. aureusmurine pyelonephritisgram-positivegram-negativeanaerobicInhibitorinhibitorinhibit

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