2. TGF-beta/Smad Stem Cell/Wnt
  3. TGF-β Receptor TGF-beta/Smad
  4. TGFβRII-IN-3

TGFβRII-IN-3 (Compound 2r) 是一种选择性的 TGFβ 类型 II 受体 (TGFβ RII) 的抑制剂 (IC50= 4.1 μM)。其通过促进 TGFβ RII 的蛋白质降解来抑制 TGFβ 信号传导。TGFβRI-IN-7 可以阻断内皮向间充质的转变和细胞迁移。TGFβRI-IN-7 还能够用于癌症研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

TGFβRII-IN-3 Chemical Structure

TGFβRII-IN-3 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

TGFβRII-IN-3 相关抗体

Top Publications Citing Use of Products

查看 TGF-β Receptor 亚型特异性产品:

查看所有亚型
ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TGFβRII-IN-3 (Compound 2r) is a selective inhibitor of the TGFβ type II receptor (TGFβ RII) (IC50 = 4.1 μM). TGFβRII-IN-3 inhibits TGFβ signaling by promoting the proteolytic degradation of TGFβ RII. TGFβRII-IN-3 can block endothelial-to-mesenchymal transition and cell migration. TGFβRII-IN-3 can be used in cancer research[1].

IC50 & Target[1]

TGF-βR2

4.1 μM (IC50)

体外研究
(In Vitro)

TGFβRII-IN-3 (5-15μM; 24 h) 通过降低 A549 细胞中的 Smad2 的磷酸化水平来抑制 TGFβ 信号通路的活性。并且对 TGFβ RII 的选择性降解作用[1]。
TGFβRII-IN-3 (2.5-10 μM; 48 h) 能有效抑制 A549 细胞中的由 TGFβ1 诱导的 E-cadherin 丢失，同时抑制 Snail 和 N-cadherin 的上调[1]。
TGFβRII-IN-3 (5 μM; 48h) 通过抑制 A549 和 H1299 细胞对 TGFβ 信号传导，从而抑制了细胞迁移和形态变化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TGFβRII-IN-3 相关抗体:

Western Blot Analysis[1]

Cell Line: A549 cell
Concentration: 5;10;15 μM
Incubation Time: 24h
Result: Significantly and dose-dependently inhibited TGFβ1-induced phosphorylation of Smad2 in A549 cells.
Significantly reduced the steady-state levels of TβRII in a dose-dependent manner. At the same time, the levels of TGFβ type I receptor were not significantly affected.
分子量

454.48

Formula

C26H25F3N2O2
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TGFβRII-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TGFβRII-IN-3TGF-β ReceptorTGF-beta/SmadTransforming growth factor beta receptorsTransforming growth factor betaTGFβ type II receptor inhibitorSelective TβRII degraderEMT inhibitorSmad2 phosphorylation inhibitorCancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
TGFβRII-IN-3
目录号：
HY-161398
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z