2. Apoptosis
  3. Bcl-2 Family
  4. TMX-2164

TMX-2164 是一种有效、不可逆的 B 细胞淋巴瘤 6 (BCL6) 抑制剂，其 IC50 值为 152 nM。TMX-2164 在细胞中表现出持续的靶向作用和抗增殖活性。

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TMX-2164 Chemical Structure

TMX-2164 Chemical Structure

CAS No. : 2418022-85-0

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TMX-2164 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TMX-2164 is a potent, irreversible B-cell lymphoma 6 (BCL6) inhibitor with an IC50 value of 152 nM. TMX-2164 displays sustained target engagement and antiproliferative activity in cells[1].

IC50 & Target

IC50: 152 nM (BCL6)[1]
体外研究
(In Vitro)

TMX-2164 (5 μM; 30 h; HEK293T-cells) displays sustained target engagement and to prolongs occupancy on BCL6 protein[1].
TMX-2164 (6.2 μM; 1, 3, and 5 d; SU-DHL-4 cells) exhibits single digit micromolar antiproliferative activity in SU-DHL-4 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TMX-2164 相关抗体:

Cell Viability Assay[1]

Cell Line: SU-DHL-4 cells
Concentration: 6.2 μM
Incubation Time: 1, 3, and 5 days
Result: Inhibited cell growth with 5 days.
分子量

591.01

Formula

C25H24ClFN6O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TMX-2164 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TMX-21642418022-85-0TMX2164TMX 2164Bcl-2 FamilyB-cell lymphoma 6target engagementantiproliferativeanticancerHEK293T-cellsSU-DHL-4 cellsInhibitorinhibitorinhibit

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产品名称：
TMX-2164
目录号：
HY-148281
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