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  3. Parasite
  4. Trypanothione synthetase-IN-4

Trypanothione synthetase-IN-4 

目录号: HY-151149
产品使用指南

摩尔计算器

Trypanothione synthetase-IN-4 是一个 L. infantum TryS 抑制剂，其活性依赖于多胺底物的浓度。Trypanothione synthetase-IN-4 具有较强的抗 leishmanicidal 活性，其 EC50 值为 0.6 μM，选择性指数为 35。Trypanothione synthetase-IN-4 可用于利什曼病的研究。

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Trypanothione synthetase-IN-4 Chemical Structure

Trypanothione synthetase-IN-4 Chemical Structure

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Trypanothione synthetase-IN-4 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Trypanothione synthetase-IN-4 is a L. infantum trypanothione synthetase (TryS) inhibitor, and the activity is dependent on the concentration of the polyamine substrate. Trypanothione synthetase-IN-4 has potent antileishmanicidal activity with an EC50 value of 0.6 μM and a selectivity index of 35. Trypanothione synthetase-IN-4 can be used for the research of leishmaniasis[1].

IC50 & Target

IC50 against LiTryS: 7.3 μM (ATP); 7.8 μM (GSH) and 5.5 μM (Spd)[1].
EC50: 0.4 μM (L. infantum); 0.6 μM (against intracellular amastigotes)[1].
体外研究
(In Vitro)

Trypanothione synthetase-IN-4 (15 μM) has activity against LiTryS for three substrates (ATP, GSH and Spd) with IC50 values of 7.3 μM, 7.8 μM and 5.5 μM, respectively[1].
Trypanothione synthetase-IN-4 (25 μM, 24 h) has antileishmanial activity with an EC50 value of 0.4 μM in axenic amastigotes of L. infantum[1].
Trypanothione synthetase-IN-4 (25 μM, 72 h) is active against intracellular amastigotes (EC50=0.6 μM) and has a high selectivity index of 35.5[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Trypanothione synthetase-IN-4 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HepG2 (human hepatoma cell line)
Concentration: 25 μM
Incubation Time: 72 h
Result: Showed antileishmanial activity with an EC50 value of 0.4 μM in axenic amastigotes of L. infantum.
分子量

573.63

Formula

C29H52INO2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Trypanothione synthetase-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trypanothione synthetase-IN-4ParasiteL. infantumtrypanothione synthetase (TryS)polyamineanti-leishmanicidalparasitesInhibitorinhibitorinhibit

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