2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin polymerization-IN-61

Tubulin polymerization-IN-61 (Compound 9a) 是一种微管蛋白聚合抑制剂。Tubulin polymerization-IN-61 破坏微管骨架，阻断细胞周期 G2/M 期，诱导细胞凋亡 (Apoptosis)，抑制癌细胞迁移和集落形成。Tubulin polymerization-IN-61 在 in vivo 4T1 异种移植模型中表现出抗肿瘤活性。

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Tubulin polymerization-IN-61 Chemical Structure

Tubulin polymerization-IN-61 Chemical Structure

CAS No. : 2758114-60-0

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Tubulin polymerization-IN-61 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin polymerization-IN-61 (Compound 9a) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-61 destroys the microtubule skeleton, blocks the cell cycle in G2/M phase, induces Apoptosis, and inhibits cancer cell migration and colony formation. Tubulin polymerization-IN-61 shows antitumor activity in vivo against 4T1 xenograft model[1].

体外研究
(In Vitro)

Tubulin polymerization-IN-61 对三种人类癌细胞系 (MCF-7、SGC-7901 和 A549) 具有抗增殖活性，IC50 值范围为 14 至 45 nM[1]。
Tubulin polymerization-IN-61 (20-60 nM,24 h) 将 MCF-7 细胞 G2/M 周期比例从 14% 增加至 50%，诱导细胞凋亡，并抑制 MCF-7 细胞迁移和集落形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-61 相关抗体:
体内研究
(In Vivo)

Tubulin polymerization-IN-61 (5 或 15 mg/kg，静脉注射，每两天一次，持续 2 周) 在 BALB/c 小鼠 4T1 异种移植肿瘤模型中显示出抗肿瘤作用，且毒性可忽略不计[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

407.42

Formula

C22H21N3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin polymerization-IN-61 相关分类

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Keywords:

Tubulin polymerization-IN-612758114-60-0Microtubule/TubulinApoptosis4T1tumorMCF-7SGC-7901A549Inhibitorinhibitorinhibit

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